EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
2.1.1.63 | K107L | mutant is deficient in DNA repair | Homo sapiens |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.1.1.63 | methyl iodide | can directly alkylate the active site of the enzyme, the agent can increase the effectiveness of environmental and endogenously produced alkylating carcinogens in producing the mutagenic 6-O-alkylguanine residue in DNA in vivo | Homo sapiens |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.1.1.63 | DNA containing 6-O-methylguanine + [protein]-L-cysteine | Homo sapiens | the enzyme repairs DNA by transferring alkyl (R)-adducts from 6-O-alkylguanine in DNA to its own cysteine residue at codon 145 | DNA lacking 6-O-methylguanine + [protein]-S-methyl-L-cysteine | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.1.1.63 | Homo sapiens | - |
- |
- |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.1.1.63 | DNA containing 6-O-methylguanine + [protein]-L-cysteine | the enzyme repairs DNA by transferring alkyl (R)-adducts from 6-O-alkylguanine in DNA to its own cysteine residue at codon 145 | Homo sapiens | DNA lacking 6-O-methylguanine + [protein]-S-methyl-L-cysteine | - |
? |