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Literature summary extracted from

  • Fritz, T.A.; Liu, L.; Finer-Moore, J.S.; Stroud, R.M.
    Tryptophan 80 and leucine 143 are critical for the hydride transfer step of thymidylate synthase by controlling active site access (2002), Biochemistry, 41, 7021-7029.
    View publication on PubMed

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
2.1.1.45 crystals grown by the hanging drop vapor diffusion method Escherichia coli

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.1.45 5,10-methylenetetrahydrofolate + dUMP Escherichia coli
-
 dihydrofolate + dTMP
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.45 Escherichia coli P0A884
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.1.1.45
-
 Escherichia coli

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.45 5,10-methylenetetrahydrofolate + dUMP
-
 Escherichia coli dihydrofolate + dTMP
-
 ?
2.1.1.45 5,10-methylenetetrahydrofolate + dUMP
-
 Escherichia coli dihydrofolate + dTMP
-
 r

Cofactor

EC Number Cofactor Comment Organism Structure
2.1.1.45 (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate
-
 Escherichia coli