Literature summary extracted from

Chen, S.C.; Daron, H.H.; Aull, J.L.
Inhibition of thymidylate synthase by pyridoxal phosphate (1989), Int. J. Biochem., 21, 1217-1221.

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
2.1.1.45	pyridoxal 5'-phosphate	-	Lacticaseibacillus casei

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
2.1.1.45	5,10-methylenetetrahydrofolate + dUMP	Lacticaseibacillus casei	-	dihydrofolate + dTMP	-	?

Organism

EC Number	Organism	UniProt	Comment	Textmining
2.1.1.45	Lacticaseibacillus casei	-	-	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2.1.1.45	5,10-methylenetetrahydrofolate + dUMP	-	Lacticaseibacillus casei	dihydrofolate + dTMP	-	?
2.1.1.45	5,10-methylenetetrahydrofolate + dUMP	-	Lacticaseibacillus casei	dihydrofolate + dTMP	-	r

Ki Value [mM]

EC Number	Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
2.1.1.45	0.6	0.9	pyridoxal 5'-phosphate	-	Lacticaseibacillus casei

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Release 2023.1 (January 2023)