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Literature summary extracted from

  • Mertes, M.P.; Chang, C.T.C.; de Clercq, E.; Huang, G.F.; Torrence, P.F.
    5-Nitro-2-deoxyuridine 5-monophosphate is a potent irreversible inhibitor of Lactobacillus caesi thymidylate synthetase (1978), Biochem. Biophys. Res. Commun., 84, 1054-1059.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.1.1.45 5-fluoro-2'-deoxyuridine 5'-monophosphate
-
 Lacticaseibacillus casei
2.1.1.45 5-fluoro-2'-deoxyuridylic acid
-
 Lacticaseibacillus casei
2.1.1.45 5-iodo-2'-deoxyuridylic acid
-
 Lacticaseibacillus casei
2.1.1.45 5-Nitro-2'-deoxyuridine 5'-monophosphate
-
 Lacticaseibacillus casei
2.1.1.45 5-nitro-2'-deoxyuridylic acid
-
 Lacticaseibacillus casei
2.1.1.45 5-trifluoromethyl-2'-deoxyuridine 5'-monophosphate
-
 Lacticaseibacillus casei

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.1.1.45 0.0015
-
 2'-deoxyuridine 5'-monophosphate
-
 Lacticaseibacillus casei

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.1.45 5,10-methylenetetrahydrofolate + dUMP Lacticaseibacillus casei
-
 dihydrofolate + dTMP
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.45 Lacticaseibacillus casei
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.1.1.45
-
 Lacticaseibacillus casei

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.45 5,10-methylenetetrahydrofolate + dUMP
-
 Lacticaseibacillus casei dihydrofolate + dTMP
-
 ?
2.1.1.45 5,10-methylenetetrahydrofolate + dUMP
-
 Lacticaseibacillus casei dihydrofolate + dTMP
-
 r

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.1.1.45 0.000014
-
 5-fluoro-2'-deoxyuridine 5'-monophosphate
-
 Lacticaseibacillus casei
2.1.1.45 0.000029
-
 5-Nitro-2'-deoxyuridine 5'-monophosphate
-
 Lacticaseibacillus casei
2.1.1.45 0.000039
-
 5-trifluoromethyl-2'-deoxyuridine 5'-monophosphate
-
 Lacticaseibacillus casei