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Literature summary extracted from

  • Kisliuk, R.L.; Gaumont, Y.
    Polyglutamyl derivatives of folate as substrates and inhibitors of thymidylate synthetase (1974), J. Biol. Chem., 249, 4100-4103.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.1.1.45 (6R)-tetrahydropteroylglutamate
-
 Lacticaseibacillus casei
2.1.1.45 dihydropteroylhexaglutamate
-
 Lacticaseibacillus casei
2.1.1.45 dihydropteroyltriglutamate
-
 Lacticaseibacillus casei
2.1.1.45 pteroylhexaglutamate
-
 Lacticaseibacillus casei
2.1.1.45 pteroylpolyglutamate
-
 Lacticaseibacillus casei

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.1.1.45 0.025
-
 (l)-tetrahydropteroyltriglutamate
-
 Lacticaseibacillus casei
2.1.1.45 0.061
-
 (6S)-tetrahydropteroylglutamate
-
 Lacticaseibacillus casei
2.1.1.45 0.077
-
 tetrahydropteroylglutamate
-
 Lacticaseibacillus casei

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.1.45 5,10-methylenetetrahydrofolate + dUMP Lacticaseibacillus casei
-
 dihydrofolate + dTMP
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.45 Lacticaseibacillus casei
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.45 (6S)-methylenetetrahydropteroylhexaglutamate + 2'-deoxyuridylate
-
 Lacticaseibacillus casei 7,8-dihydropteroylhexaglutamate + thymidine phosphate
-
 r
2.1.1.45 (6S)-tetrahydropteroylglutamate + 2-deoxyuridylate
-
 Lacticaseibacillus casei 7,8-dihydropteroylglutamate + thymidine phosphate
-
 r
2.1.1.45 (6S)-tetrahydropteroyltriglutamate + 2'-deoxyuridylate
-
 Lacticaseibacillus casei 7,8-dihydropteroyltriglutamate + thymidine phosphate
-
 r
2.1.1.45 5,10-methylenetetrahydrofolate + dUMP
-
 Lacticaseibacillus casei dihydrofolate + dTMP
-
 ?
2.1.1.45 5,10-methylenetetrahydrofolate + dUMP
-
 Lacticaseibacillus casei dihydrofolate + dTMP
-
 r