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Literature summary extracted from

  • Yeates, T.O.
    Structures of SET domain proteins: protein lysine methyltransferases make their mark (2002), Cell, 111, 5-7.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.1.127 S-adenosyl-L-methionine + histone L-lysine Pisum sativum
-
 S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine
-
 ?
2.1.1.354 S-adenosyl-L-methionine + histone L-lysine Homo sapiens
-
 S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine
-
 ?
2.1.1.355 S-adenosyl-L-methionine + histone L-lysine Neurospora crassa
-
 S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.127 Pisum sativum
-
-
-
2.1.1.354 Homo sapiens
-
 SET9, also called SET7
-
2.1.1.355 Neurospora crassa
-
 DIM-5 protein
-

Reaction

EC Number Reaction Comment Organism Reaction ID
2.1.1.127 S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine enzyme is encoded on genes containing the SET-domain sequence, substrate specificity is connected to SET sequence Pisum sativum
a
2.1.1.127 S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine SET structure Pisum sativum
a
2.1.1.354 S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine enzyme is encoded on genes containing the SET-domain sequence, substrate specificity is connected to SET sequence Homo sapiens
a
2.1.1.354 S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine SET structure Homo sapiens
a
2.1.1.355 S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine enzyme is encoded on genes containing the SET-domain sequence, substrate specificity is connected to SET sequence Neurospora crassa
a
2.1.1.355 S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine SET structure Neurospora crassa
a
2.1.1.355 S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine H3-Lys9 methylation is catalyzed by the Suv39h family proteins Neurospora crassa
a

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.127 S-adenosyl-L-methionine + histone L-lysine
-
 Pisum sativum S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine
-
 ?
2.1.1.354 S-adenosyl-L-methionine + histone L-lysine
-
 Homo sapiens S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine
-
 ?
2.1.1.355 S-adenosyl-L-methionine + histone L-lysine
-
 Neurospora crassa S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine
-
 ?