EC Number | Cloned (Comment) | Organism |
---|---|---|
2.1.1.127 | overexpression in Escherichia coli BL21, His-tagged protein | Pisum sativum |
EC Number | Crystallization (Comment) | Organism |
---|---|---|
2.1.1.127 | complexed with S-adenosyl-L-homocysteine, hanging drop method, 25°C, reservoir solution contains HEPES 100 mM, pH 6.8, sodium acetate 1.2-1.35 M, structure analysis | Pisum sativum |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.1.1.127 | S-adenosyl-L-homocysteine | - |
Pisum sativum |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.1.1.127 | additional information | Pisum sativum | histone methylation has significant effects on heterochromatin formation and transcriptional regulation | ? | - |
? | |
2.1.1.127 | S-adenosyl-L-methionine + histone L-lysine | Pisum sativum | - |
S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.1.1.127 | Pisum sativum | - |
- |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
2.1.1.127 | recombinant from E. coli | Pisum sativum |
EC Number | Reaction | Comment | Organism | Reaction ID |
---|---|---|---|---|
2.1.1.127 | S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine | catalytic mechanism | Pisum sativum | |
2.1.1.127 | S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine | substrate and inhibitor binding site | Pisum sativum | |
2.1.1.127 | S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine | amino acid sequence comparison | Pisum sativum | |
2.1.1.127 | S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine | enzyme is encoded on genes containing the SET-domain sequence, substrate specificity is connected to SET sequence | Pisum sativum |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.1.1.127 | additional information | histone methylation has significant effects on heterochromatin formation and transcriptional regulation | Pisum sativum | ? | - |
? | |
2.1.1.127 | S-adenosyl-L-methionine + histone L-lysine | - |
Pisum sativum | S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine | - |
? |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
2.1.1.127 | 30 | - |
assay at | Pisum sativum |