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Literature summary extracted from

  • Mukhtar, H.; Hakkou, A.; Bonaly, R.
    Studies on the activity of Kluyveromyces lactis S-adenosylmethionine:DELTA 24-sterol methyltransferase in presence of polyenic antifungal agents (1994), Mycopathologia, 126, 75-83.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.1.1.41 amphotericine B activates at concentrations below 5.4 nM, optimal at 2.1 nM, wild-type and mutant Kluyveromyces lactis
2.1.1.41 candicidin stimulates, best at low concentration Kluyveromyces lactis
2.1.1.41 Filipin slightly activating at high concentration Kluyveromyces lactis
2.1.1.41 Nystatin slightly activating at high concentration Kluyveromyces lactis
2.1.1.41 pimaricin strong activation, activation level decreases with increasing concentration of pimaricin Kluyveromyces lactis

Protein Variants

EC Number Protein Variants Comment Organism
2.1.1.41 additional information natural amphotericine B-resistant mutant strain Kluyveromyces lactis

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.1.1.41 amphotericine B inhibits the wild-type at concentrations above 60 nM, inhibition can be hindered by zymosterol Kluyveromyces lactis
2.1.1.41 Filipin slightly inhibiting at low concentration Kluyveromyces lactis
2.1.1.41 Nystatin slightly inhibiting at low concentration Kluyveromyces lactis

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.1.41 zymosterol + S-adenosyl-L-methionine Kluyveromyces lactis
-
 fecosterol + S-adenosyl-L-homocysteine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.41 Kluyveromyces lactis
-
 yeast
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.41 zymosterol + S-adenosyl-L-methionine
-
 Kluyveromyces lactis fecosterol + S-adenosyl-L-homocysteine
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.1.1.41 35
-
 assay at Kluyveromyces lactis

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.1.1.41 7.6
-
 assay at Kluyveromyces lactis