EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.1.1.37 | KCl | above 100 mM | Mus musculus | |
2.1.1.37 | NaCl | above 100 mM | Mus musculus |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.1.1.37 | 0.0003 | - |
poly(dI-dC)-poly(dI-dC) | isoenzyme Dnmt3a | Mus musculus | |
2.1.1.37 | 0.0003 | - |
S-adenosyl-L-methionine | isoenzyme Dnmt3a, reaction with poly(dG-dC)-poly(dG-dC) | Mus musculus | |
2.1.1.37 | 0.0004 | - |
S-adenosyl-L-methionine | isoenzyme Dnmt3a, reaction with poly(dI-dC)-poly(dI-dC) | Mus musculus | |
2.1.1.37 | 0.0008 | - |
S-adenosyl-L-methionine | isoenzyme Dnmt3b2, reaction with poly(dG-dC)-poly(dG-dC) | Mus musculus | |
2.1.1.37 | 0.0009 | - |
S-adenosyl-L-methionine | isoenzyme Dnmt3b2, reaction with poly(dI-dC)-poly(dI-dC) | Mus musculus | |
2.1.1.37 | 0.0009 | - |
poly(dG-dC)-poly(dG-dC) | isoenzyme Dnmt3b2 | Mus musculus | |
2.1.1.37 | 0.001 | - |
poly(dG-dC)-poly(dG-dC) | isoenzyme Dnmt3b1 | Mus musculus | |
2.1.1.37 | 0.0012 | - |
S-adenosyl-L-methionine | isoenzyme Dnmt3b1, reaction with poly(dI-dC)-poly(dI-dC) por poly(dG-dC)*poly(dG-dC) | Mus musculus | |
2.1.1.37 | 0.0013 | - |
poly(dI-dC)-poly(dI-dC) | isoenzyme Dnmt3b1 | Mus musculus | |
2.1.1.37 | 0.0015 | - |
poly(dI-dC)-poly(dI-dC) | isoenzyme Dnmt3b2 | Mus musculus | |
2.1.1.37 | 0.0027 | - |
poly(dG-dC)-poly(dG-dC) | isoenzyme Dnmt3a | Mus musculus | |
2.1.1.37 | 0.0035 | - |
poly(dG-dC)-poly(dG-dC) | isoenzyme Dnmt3a | Mus musculus |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.1.1.37 | Mus musculus | - |
- |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
2.1.1.37 | recombinant Dnmt3a, Dnmt3b1 and Dnmt3b2, GST-fused Dnmt3 | Mus musculus |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.1.1.37 | S-adenosyl-L-methionine + DNA | - |
Mus musculus | S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine | - |
? | |
2.1.1.37 | S-adenosyl-L-methionine + DNA | isoenzymes Dnmt3a, Dnmt3b1 and Dnmt3b2 show similar activity towards poly(dG-dC)-poly(dG-dC) | Mus musculus | S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine | - |
? | |
2.1.1.37 | S-adenosyl-L-methionine + poly(dG-dC)-poly(dG-dC) | - |
Mus musculus | ? | - |
? | |
2.1.1.37 | S-adenosyl-L-methionine + poly(dI-dC)-poly(dI-dC) | - |
Mus musculus | ? | - |
? |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
2.1.1.37 | More | the apparent molecular weights of the GST-fused Dnmt3a, Dnmt3b1 and Dnmt3b2 are 130000 Da, 120000 Da and 115000 Da, as determined by SDS-PAGE | Mus musculus |