Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Flynn, J.; Reich, N.
    Murine DNA (cytosine-5-)methyltransferase: steady-state and substrate trapping analyses of the kinetic mechanism (1989), Biochemistry, 37, 15162-15169.
    View publication on PubMed

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.1.1.37 0.000125
-
 poly(dI*dC-dI*dC) of chain length 2000
-
 Mus musculus
2.1.1.37 0.00014
-
 poly(dI*dC-dI*dC) of chain length 5000
-
 Mus musculus
2.1.1.37 0.0003
-
 poly(dI*dC-dI*dC) of chain length 500
-
 Mus musculus
2.1.1.37 0.00189
-
 poly(dI*dC-dI*dC) of chain length 100
-
 Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.1.37 additional information Mus musculus the enzyme is essential for viable mammalian development and has a central function in the determination and maintenance of epigenetic methalation pattern ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.37 Mus musculus
-
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
2.1.1.37 S-adenosyl-L-methionine + DNA containing cytosine = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine sequential ordered bi-bi kinetic mechanism in which DNA binds to the enzyme first, followed by S-adenosyl-L-homocysteine and methylated DNA are released, formation of an enzyme-DNA-DNA ternary complex Mus musculus
a

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.1.1.37 erythroleukemia cell
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.37 additional information the enzyme is essential for viable mammalian development and has a central function in the determination and maintenance of epigenetic methalation pattern Mus musculus ?
-
 ?
2.1.1.37 S-adenosyl-L-methionine + DNA
-
 Mus musculus S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine
-
 ?
2.1.1.37 S-adenosyl-L-methionine + DNA poly(dI*dC-dI*dC) of chain length 100, 500, 2000 or 5000 base pairs Mus musculus S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine
-
 ?
2.1.1.37 S-adenosyl-L-methionine + poly(dI*dC-dI*dC) of chain length 100
-
 Mus musculus ?
-
 ?
2.1.1.37 S-adenosyl-L-methionine + poly(dI*dC-dI*dC) of chain length 2000
-
 Mus musculus ?
-
 ?
2.1.1.37 S-adenosyl-L-methionine + poly(dI*dC-dI*dC) of chain length 500
-
 Mus musculus ?
-
 ?
2.1.1.37 S-adenosyl-L-methionine + poly(dI*dC-dI*dC) of chain length 5000
-
 Mus musculus ?
-
 ?

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
2.1.1.37 0.00597
-
 poly(dI*dC-dI*dC) of chain length 100
-
 Mus musculus
2.1.1.37 0.00633
-
 poly(dI*dC-dI*dC) of chain length 500
-
 Mus musculus
2.1.1.37 0.00692
-
 poly(dI*dC-dI*dC) of chain length 2000
-
 Mus musculus
2.1.1.37 0.00867
-
 poly(dI*dC-dI*dC) of chain length 5000
-
 Mus musculus