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Literature summary extracted from

  • Shaw, W.V.; Tsai, L.; Stadtman, E.R.
    The enzymatic synthesis of N-methylglutamic acid (1966), J. Biol. Chem., 241, 935-945.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.1.1.21 ammonia competitive with respect to methylamine Pseudomonas sp.
2.1.1.21 arsenite
-
 Pseudomonas sp.
2.1.1.21 hydroxylamine reversible Pseudomonas sp.
2.1.1.21 iodoacetate
-
 Pseudomonas sp.
2.1.1.21 N-ethylmaleimide
-
 Pseudomonas sp.
2.1.1.21 p-chloromercuribenzoate
-
 Pseudomonas sp.

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.1.21 methylamine + L-glutamate Pseudomonas sp. involved in one carbon metabolism NH3 + N-methyl-L-glutamate
-
 r
2.1.1.21 methylamine + L-glutamate Pseudomonas sp. AM1(2006) involved in one carbon metabolism NH3 + N-methyl-L-glutamate
-
 r

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.21 Pseudomonas sp.
-
 no activity when grown without methylamine in growth medium
-
2.1.1.21 Pseudomonas sp. AM1(2006)
-
 no activity when grown without methylamine in growth medium
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.21 methylamine + L-glutamate
-
 Pseudomonas sp. NH3 + N-methyl-L-glutamate
-
 r
2.1.1.21 methylamine + L-glutamate involved in one carbon metabolism Pseudomonas sp. NH3 + N-methyl-L-glutamate
-
 r
2.1.1.21 methylamine + L-glutamate
-
 Pseudomonas sp. AM1(2006) NH3 + N-methyl-L-glutamate
-
 r
2.1.1.21 methylamine + L-glutamate involved in one carbon metabolism Pseudomonas sp. AM1(2006) NH3 + N-methyl-L-glutamate
-
 r
2.1.1.21 methylamine + L-glutamate-gamma-methylester
-
 Pseudomonas sp. NH3 + N-methyl-L-glutamate-gamma-methyl ester
-
 r
2.1.1.21 methylamine + L-glutamate-gamma-methylester
-
 Pseudomonas sp. AM1(2006) NH3 + N-methyl-L-glutamate-gamma-methyl ester
-
 r
2.1.1.21 methylamine + L-glutamine
-
 Pseudomonas sp. ?
-
 r
2.1.1.21 methylamine + L-glutamine
-
 Pseudomonas sp. AM1(2006) ?
-
 r

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.1.1.21 8.3
-
-
 Pseudomonas sp.

pH Range

EC Number pH Minimum pH Maximum Comment Organism
2.1.1.21 7 9
-
 Pseudomonas sp.

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.1.1.21 49
-
 ammonia
-
 Pseudomonas sp.