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Literature summary extracted from

  • Konishi, K.; Fujioka, M.
    Reversible inactivation of recombinant rat liver guanidinoacetate methyltransferase by glutathione disulfide (1991), Arch. Biochem. Biophys., 289, 90-96.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.1.1.2
-
 Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.1.1.2 glutathione readily reactivated by reduced glutathione, substrates do not protect against inactivation, guanidinoacetate together with sinefungin protects against inactivation, can be reactivated with thiol compounds Rattus norvegicus
2.1.1.2 sinefungin competitive with S-adenosylmethionine Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.1.2 S-adenosyl-L-methionine + guanidinoacetate Rattus norvegicus
-
 S-adenosyl-L-homocysteine + creatine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.2 Rattus norvegicus
-
 expressed in Escherichia coli
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.1.1.2 liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.2 S-adenosyl-L-methionine + guanidinoacetate
-
 Rattus norvegicus S-adenosyl-L-homocysteine + creatine
-
 ?