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Literature summary extracted from

  • Im, Y.S.; Chiang, P.K.; Cantoni, G.L.
    Guanidoacetate methyltransferase. Purification and molecular properties (1979), J. Biol. Chem., 254, 11047-11050.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.1.1.2 3-deaza-S-adenosyl-L-homocysteine competitive with S-adenosylmethionine Sus scrofa
2.1.1.2 S-adenosyl-L-homocysteine competitive with S-adenosylmethionine Sus scrofa
2.1.1.2 sinefungin competitive with S-adenosylmethionine Sus scrofa

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.1.1.2 0.027
-
Guanidinoacetate
-
Sus scrofa
2.1.1.2 0.049
-
S-adenosyl-L-methionine
-
Sus scrofa

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.1.1.2 31000
-
SDS-PAGE, native PAGE without SDS yields heterogeneity in molecular weight Sus scrofa
2.1.1.2 31500
-
gel filtration Sus scrofa

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.1.2 S-adenosyl-L-methionine + guanidinoacetate Sus scrofa
-
S-adenosyl-L-homocysteine + creatine
-
?

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.2 Sus scrofa
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.1.1.2
-
Sus scrofa

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.1.1.2 liver
-
Sus scrofa
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.1.1.2 27.2
-
purified enzyme Sus scrofa

Storage Stability

EC Number Storage Stability Organism
2.1.1.2 -60°C, purified enzyme, stable for months Sus scrofa

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.2 S-adenosyl-L-methionine + guanidinoacetate
-
Sus scrofa S-adenosyl-L-homocysteine + creatine
-
?

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.1.1.2 0.016
-
adenosylhomocysteine
-
Sus scrofa
2.1.1.2 0.018
-
sinefungin
-
Sus scrofa
2.1.1.2 0.039
-
3-deaza-S-adenosyl-L-homocysteine
-
Sus scrofa