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Literature summary extracted from

  • De Busser, H.M.; Van Dessel, G.A.F.; Lagrou, A.R.
    Identification of prenylcysteine carboxymethyltransferase in bovine adrenal chromaffin cells (2000), Int. J. Biochem. Cell Biol., 32, 1007-1016.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.1.1.100 Ca2+ moderate inhibition Bos taurus
2.1.1.100 CTAB 0.1%, more than 90% inhibition Bos taurus
2.1.1.100 Cu2+ complete inhibition Bos taurus
2.1.1.100 deoxycholate 0.1%, 51% inhibition Bos taurus
2.1.1.100 dimethylsulfoxid more than 4% cause inhibition Bos taurus
2.1.1.100 Hg2+ complete inhibition Bos taurus
2.1.1.100 Mg2+ moderate inhibition Bos taurus
2.1.1.100 Mn2+ moderate inhibition Bos taurus
2.1.1.100 mono iodoacetate moderate inhibition Bos taurus
2.1.1.100 N-ethylmaleimide moderate inhibition Bos taurus
2.1.1.100 Nonidet P40 0.1%, 73% inhibition Bos taurus
2.1.1.100 S-adenosyl-L-homocysteine 0.005 mM, 50% inhibition Bos taurus
2.1.1.100 S-Farnesylthioacetic acid 0.048 mM, 50% inhibition Bos taurus
2.1.1.100 sinefungin 0.0035 mM, 50% inhibition Bos taurus
2.1.1.100 Triton X-100 0.1%, 63% inhibition Bos taurus
2.1.1.100 Tween 80 0.1%, 33% inhibition Bos taurus
2.1.1.100 Zn2+ complete inhibition Bos taurus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.1.1.100 0.004
-
 S-adenosyl-L-methionine
-
 Bos taurus
2.1.1.100 0.052
-
 N-acetyl-S-geranylgeranyl-L-cysteine
-
 Bos taurus
2.1.1.100 0.09
-
 N-acetyl-S-(E,E)-farnesyl-L-cysteine
-
 Bos taurus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.1.1.100 membrane
-
 Bos taurus 16020
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.1.1.100 Li+ slight stimulation Bos taurus

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.100 Bos taurus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.1.1.100 adrenal gland adrenal chromaffin cells Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.100 S-adenosyl-L-methionine + N-acetyl-S-geranylgeranyl-L-cysteine
-
 Bos taurus S-adenosyl-L-homocysteine + N-acetyl-S-geranylgeranyl-L-cysteine methyl ester
-
 ?
2.1.1.100 S-adenosylmethionine + N-acetyl-S-(E,E)-farnesyl-L-cysteine
-
 Bos taurus S-adenosylhomocysteine + N-acetyl-S-(E,E)-farnesyl-L-cysteine methyl ester
-
 ?

pH Range

EC Number pH Minimum pH Maximum Comment Organism
2.1.1.100 7.4 8
-
 Bos taurus