Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Giner, J.L.; Rando, R.R.
    Novel methyltransferase activity modifying the carboxy terminal bis(geranylgeranyl)-Cys-Ala-Cys structure of small GTP-binding proteins (1994), Biochemistry, 33, 15116-15123.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.1.1.100 S-adenosyl-L-homocysteine
-
 Bos taurus
2.1.1.100 S-adenosylethionine
-
 Bos taurus
2.1.1.100 S-Farnesylthioacetic acid
-
 Bos taurus
2.1.1.100 sinefungin
-
 Bos taurus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.1.1.100 0.0036
-
 S-adenosyl-L-methionine
-
 Bos taurus
2.1.1.100 0.0565
-
 N-acetyl-S-(E,E)-farnesyl-L-cysteine
-
 Bos taurus
2.1.1.100 0.594
-
 N-acetyl-S-geranylgeranyl-L-cysteinyl-L-alanyl-S-geranylgeranyl-L-cysteine
-
 Bos taurus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.1.1.100 membrane
-
 Bos taurus 16020
-

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.100 Bos taurus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.1.1.100 brain
-
 Bos taurus
-
2.1.1.100 heart
-
 Bos taurus
-
2.1.1.100 intestine
-
 Bos taurus
-
2.1.1.100 kidney
-
 Bos taurus
-
2.1.1.100 liver
-
 Bos taurus
-
2.1.1.100 lung
-
 Bos taurus
-
2.1.1.100 retina
-
 Bos taurus
-
2.1.1.100 retinal rod outer segment Bos taurus
-
2.1.1.100 testis
-
 Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.100 S-adenosyl-L-methionine + N-acetyl-S-geranylgeranyl-L-cysteinyl-L-alanyl-S-geranylgeranyl-L-cysteine no activity with + N-acetyl-S-geranylgeranyl-L-cysteinyl-S-geranylgeranyl-L-cysteine Bos taurus S-adenosyl-L-homocysteine + N-acetyl-S-geranylgeranyl-L-cysteinyl-L-alanyl-S-geranylgeranyl-L-cysteine methyl ester
-
 ?
2.1.1.100 S-adenosylmethionine + N-acetyl-S-(E,E)-farnesyl-L-cysteine
-
 Bos taurus S-adenosylhomocysteine + N-acetyl-S-(E,E)-farnesyl-L-cysteine methyl ester
-
 ?

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.1.1.100 0.000296
-
 sinefungin inhibition of N-acetyl-S-geranylgeranyl-L-cysteinyl-L-alanyl-S-geranylgeranyl-L-cysteine Bos taurus
2.1.1.100 0.000318
-
 sinefungin inhibition of N-acetyl-S-(E,E)-farnesyl-L-cysteine methylation Bos taurus
2.1.1.100 0.00645
-
 S-adenosylethionine inhibition of N-acetyl-S-(E,E)-farnesyl-L-cysteine methylation Bos taurus
2.1.1.100 0.00658
-
 S-adenosyl-L-homocysteine inhibition of N-acetyl-S-(E,E)-farnesyl-L-cysteine methylation Bos taurus
2.1.1.100 0.0112
-
 S-Farnesylthioacetic acid inhibition of N-acetyl-S-(E,E)-farnesyl-L-cysteine methylation Bos taurus
2.1.1.100 0.0115
-
 S-adenosyl-L-homocysteine inhibition of N-acetyl-S-geranylgeranyl-L-cysteinyl-L-alanyl-S-geranylgeranyl-L-cysteine Bos taurus
2.1.1.100 0.0218
-
 S-adenosylethionine inhibition of N-acetyl-S-geranylgeranyl-L-cysteinyl-L-alanyl-S-geranylgeranyl-L-cysteine Bos taurus