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Literature summary extracted from

  • Pillinger, M.H.; Volker, C.; Stock, J.B.; Weissmann, G.; Philips, M.R.
    Characterization of a plasma membrane-associated prenylcysteine-directed a carboxyl methyltransferase in human neutrophils (1994), J. Biol. Chem., 269, 1486-1492.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.1.1.100 formyl-methionine-leucine-phenylalanine stimulation of carboxyl methylation of GTP-binding proteins through a substrate-dependent mechanism Homo sapiens

General Stability

EC Number General Stability Organism
2.1.1.100 complete loss of activity after exposure to detergent e.g. CHAPS, octyl-beta-glucoside and sodium deoxycholate, activity can be reconstituted by removal of the detergent in the presence of phospholipid Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.1.1.100 5'-deoxymethylthioadenosine
-
Homo sapiens
2.1.1.100 S-adenosyl-L-homocysteine
-
Homo sapiens
2.1.1.100 sinefungin
-
Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.1.1.100 0.0013
-
S-adenosyl-L-methionine
-
Homo sapiens
2.1.1.100 0.0014
-
N-acetyl-S-geranylgeranyl-L-cysteine
-
Homo sapiens
2.1.1.100 0.0116
-
N-acetyl-S-(E,E)-farnesyl-L-cysteine
-
Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.100 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.1.1.100 blood
-
Homo sapiens
-
2.1.1.100 neutrophil light membrane fraction Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.100 S-adenosyl-L-methionine + N-acetyl-S-geranylgeranyl-L-cysteine
-
Homo sapiens S-adenosyl-L-homocysteine + N-acetyl-S-geranylgeranyl-L-cysteine methyl ester
-
?
2.1.1.100 S-adenosylmethionine + N-acetyl-S-(E,E)-farnesyl-L-cysteine
-
Homo sapiens S-adenosylhomocysteine + N-acetyl-S-(E,E)-farnesyl-L-cysteine methyl ester
-
?

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.1.1.100 0.00007
-
sinefungin
-
Homo sapiens
2.1.1.100 0.00157
-
S-adenosyl-L-homocysteine
-
Homo sapiens
2.1.1.100 3.95
-
5'-deoxymethylthioadenosine
-
Homo sapiens