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Literature summary extracted from

  • Perez-Sala, D.; Gilbert, B.A.; Tan, E.W.; Rando, R.R.
    Prenylated protein methyltransferases do not distinguish between farnesylated and geranylgeranylated substrates (1992), Biochem. J., 284, 835-840.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.1.1.100 N-acetyl-S-(E,E)-farnesyl-L-cysteine
-
 Bos taurus
2.1.1.100 N-acetyl-S-(E,E)-geranylgeranyl-L-cysteine
-
 Bos taurus
2.1.1.100 N-acetyl-S-geranylgeranyl-L-cysteine inhibition of N-acetyl-S-farnesyl-L-cysteine methylation Bos taurus
2.1.1.100 S-(Geranylgeranyl-2-thio)acetic acid
-
 Bos taurus
2.1.1.100 S-Farnesylthioacetic acid
-
 Bos taurus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.1.1.100 0.0192
-
 N-acetyl-S-geranylgeranyl-L-cysteine
-
 Bos taurus
2.1.1.100 0.0223
-
 N-acetyl-S-farnesyl-L-cysteine
-
 Bos taurus

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.100 Bos taurus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.1.1.100 retina
-
 Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.100 S-adenosyl-L-methionine + N-acetyl-S-geranylgeranyl-L-cysteine
-
 Bos taurus S-adenosyl-L-homocysteine + N-acetyl-S-geranylgeranyl-L-cysteine methyl ester
-
 ?
2.1.1.100 S-adenosylmethionine + N-acetyl-S-(E,E)-farnesyl-L-cysteine
-
 Bos taurus S-adenosylhomocysteine + N-acetyl-S-(E,E)-farnesyl-L-cysteine methyl ester
-
 ?

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.1.1.100 0.0023
-
 N-acetyl-S-(E,E)-geranylgeranyl-L-cysteine competitive vs. N-acetyl-S-(E,E)-farnesyl-L-cysteine Bos taurus
2.1.1.100 0.0026
-
 N-acetyl-S-(E,E)-farnesyl-L-cysteine competitive vs. N-acetyl-S-(E,E)-geranylgeranyl-L-cysteine Bos taurus
2.1.1.100 0.0039
-
 S-(Geranylgeranyl-2-thio)acetic acid competitive vs. N-acetyl-S-(E,E)-farnesyl-L-cysteine Bos taurus
2.1.1.100 0.0046
-
 S-Farnesylthioacetic acid competitive vs. N-acetyl-S-(E,E)-farnesyl-L-cysteine Bos taurus