Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Shi, Y.Q.; Rando, R.R.
    Kinetic mechanism of isoprenylated protein methyltransferase (1992), J. Biol. Chem., 267, 9547-9551.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.1.1.100 methyl ester of N-acetyl-S-farnesyl-L-cysteine
-
 Bos taurus
2.1.1.100 N-acetyl-S-(E,E)-farnesyl-L-cysteine methyl ester mixed-type vs. N-acetyl-S-(E,E)-farnesyl-L-cysteine Bos taurus
2.1.1.100 S-adenosyl-L-homocysteine competitive vs. S-adenosyl-L-methionine, mixed-type vs. N-acetyl-S-(E,E)-farnesyl-L-cysteine Bos taurus
2.1.1.100 S-Farnesylthioacetic acid competitive vs. N-acetyl-S-(E,E)-farnesyl-L-cysteine Bos taurus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.1.1.100 0.02
-
 N-acetyl-S-(E,E)-farnesyl-L-cysteine
-
 Bos taurus

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.100 Bos taurus
-
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
2.1.1.100 S-adenosyl-L-methionine + protein C-terminal S-farnesyl-L-cysteine = S-adenosyl-L-homocysteine + protein C-terminal S-farnesyl-L-cysteine methyl ester kinetic mechanism Bos taurus
a

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.1.1.100 retina
-
 Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.100 S-adenosyl-L-methionine + protein C-terminal S-farnesyl-L-cysteine
-
 Bos taurus S-adenosyl-L-homocysteine + protein C-terminal S-farnesyl-L-cysteine methyl ester
-
 ?
2.1.1.100 S-adenosylmethionine + N-acetyl-S-(E,E)-farnesyl-L-cysteine
-
 Bos taurus S-adenosylhomocysteine + N-acetyl-S-(E,E)-farnesyl-L-cysteine methyl ester
-
 ?
2.1.1.100 S-adenosylmethionine + S-farnesyl-Leu-Ala-Arg-Tyr-Lys-Cys
-
 Bos taurus S-adenosylhomocysteine + S-farnesyl-Leu-Ala-Arg-Tyr-Lys-Cys methyl ester
-
 ?

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.1.1.100 0.0012
-
 S-Farnesylthioacetic acid
-
 Bos taurus
2.1.1.100 0.0019
-
 S-adenosyl-L-homocysteine vs. S-adenosyl-L-methionine Bos taurus
2.1.1.100 0.0033
-
 S-adenosyl-L-homocysteine vs. N-acetyl-S-(E,E)-farnesyl-L-cysteine Bos taurus
2.1.1.100 0.041
-
 N-acetyl-S-(E,E)-farnesyl-L-cysteine methyl ester
-
 Bos taurus