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Literature summary extracted from

  • Armarego, W.L.F.; Waring, P.
    Inhibition of human brain dihydropteridine reductase [E.C.1.6.99.10] by the oxidation products of catecholamines, the aminochromes (1983), Biochem. Biophys. Res. Commun., 113, 895-899.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.5.1.34 4-[(1R)-2-amino-1-hydroxyethyl]benzene-1,2-diol no inhibition below 0.2 mM Homo sapiens
1.5.1.34 Adrenochrome
-
 Homo sapiens
1.5.1.34 aminochrome oxidation product of adrenaline, competitive vs. NADH Homo sapiens
1.5.1.34 dopamine no inhibition below 0.2 mM Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.5.1.34 0.0047
-
 NADH
-
 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.5.1.34 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.5.1.34 naphthoquinone affinity chromatography, 5'-AMP-Sepharose Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.5.1.34 brain
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.5.1.34 1180
-
 enzyme from brain Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.5.1.34 6,7-dihydropteridine + NADH
-
 Homo sapiens (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + NAD+
-
 ?

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
1.5.1.34 280
-
 NADH enzyme from brain Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.5.1.34 0.0049
-
 Adrenochrome
-
 Homo sapiens