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Literature summary extracted from

  • Scrimgeour, K.G.; Cheema-Dhadli, S.
    Dihydropteridine reductase from sheep brain (1987), Methods Enzymol., 142, 127-132.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.5.1.34 HgCl2 0.002 mM, 50% inhibition, enzyme from brain Ovis aries
1.5.1.34 NAD+ competitive vs. NADH Ovis aries
1.5.1.34 p-chloromercuribenzoate 0.2 mM, 50% inhibition, enzyme from brain Ovis aries

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.5.1.34 0.01
-
 quinonoid 7,8-(6H)-dihydropterin enzyme from brain Ovis aries
1.5.1.34 0.022
-
 NADH enzyme from brain Ovis aries

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.5.1.34 27000
-
 2 * 27000, brain, SDS-PAGE Ovis aries
1.5.1.34 47000
-
 gel filtration Ovis aries

Organism

EC Number Organism UniProt Comment Textmining
1.5.1.34 Ovis aries
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.5.1.34
-
 Ovis aries

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.5.1.34 brain
-
 Ovis aries
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.5.1.34 610
-
 enzyme from brain Ovis aries

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.5.1.34 quinonoid 7,8-(6H)-dihydropterin + NADPH + H+
-
 Ovis aries 5,6,7,8-tetrahydropterin + NADP+
-
 r

Subunits

EC Number Subunits Comment Organism
1.5.1.34 dimer 2 * 27000, brain, SDS-PAGE Ovis aries

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.5.1.34 7
-
-
 Ovis aries