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Literature summary extracted from

  • Firgaira, F.A.; Cotton, R.G.H.; Jennings, I.; Danks, D.M.
    Use of naphthoquinone adsorbent for the isolation of human dihydropteridine reductase (1987), Methods Enzymol., 142, 116-126.
    View publication on PubMed

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.5.1.34 0.017
-
 5,6,7,8-tetrahydrobiopterin 37°C, pH 7.2 Homo sapiens
1.5.1.34 0.029
-
 NADPH 37°C, pH 7.2 Homo sapiens
1.5.1.34 0.036
-
 2-amino-4-hydroxy-6,7-dimethyl-5,6,7,8-tetrahydro-pteridine 37°C, pH 7.2 Homo sapiens
1.5.1.34 0.77
-
 NADH 37°C, pH 7.2 Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.5.1.34 26000
-
 2 * 26000, SDS-PAGE Homo sapiens
1.5.1.34 47500
-
 gel filtration Homo sapiens
1.5.1.34 50000
-
 sedimentation equilibrium Homo sapiens
1.5.1.34 54000
-
 gradient PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.5.1.34 quinonoid 7,8-(6H)-dihydrobiopterin + NAD(P)H Homo sapiens essential enzyme component of the complex system catalyzing hydroxylation of phenylalanine, tyrosine and tryptophan 5,6,7,8-tetrahydrobiopterin + NAD(P)+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.5.1.34 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.5.1.34
-
 Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.5.1.34 liver
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.5.1.34 422
-
-
 Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.5.1.34 2-amino-4-hydroxy-6,7-dimethyl-quinonoid-dihydropteridine + NAD(P)H
-
 Homo sapiens 2-amino-4-hydroxy-6,7-dimethyltetrahydropteridine + NAD(P)+
-
 ?
1.5.1.34 6,7-dihydropteridine + NADH
-
 Homo sapiens (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + NAD+
-
 ?
1.5.1.34 quinonoid 7,8-(6H)-dihydrobiopterin + NAD(P)H essential enzyme component of the complex system catalyzing hydroxylation of phenylalanine, tyrosine and tryptophan Homo sapiens 5,6,7,8-tetrahydrobiopterin + NAD(P)+
-
 ?

Subunits

EC Number Subunits Comment Organism
1.5.1.34 dimer 2 * 26000, SDS-PAGE Homo sapiens