EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.5.1.33 | 5-Deaza-5,6,7,8-tetrahydrofolate | - |
Leishmania major | |
1.5.1.33 | additional information | relatively insensitive to methorexate | Leishmania major | |
1.5.1.33 | NADP+ | - |
Leishmania major |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.5.1.33 | 0.001 | - |
folate | - |
Leishmania major | |
1.5.1.33 | 0.0014 | - |
NADPH | with folate as cosubstrate | Leishmania major |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.5.1.33 | Leishmania major | - |
- |
- |
EC Number | Reaction | Comment | Organism | Reaction ID |
---|---|---|---|---|
1.5.1.33 | 5,6,7,8-tetrahydrobiopterin + 2 NADP+ = biopterin + 2 NADPH + 2 H+ | ordered ternary complex mechanism with NADPH binding first and NADP+ dissociating after the reduced pteridine. The enzyme transfers the pro-S hydride of NADPH to carbon 6 on the si face of dihydrofolate | Leishmania major |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.5.1.33 | Biopterin + NADPH | - |
Leishmania major | 5,6,7,8-Tetrahydrobiopterin + NADP+ | - |
? | |
1.5.1.33 | folate + NADPH | - |
Leishmania major | 5,6,7,8-tetrahydrofolate + NADP+ | - |
? |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.5.1.33 | NADPH | - |
Leishmania major |