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Literature summary extracted from

  • Hughes, E.J.L.; Bayly, R.C.; Skurray, R.A.
    Evidence for isofunctional enzymes in the degradation of phenol, m- and p-toluate, and p-cresol via catechol meta-cleavage pathways in Alcaligenes eutrophus (1984), J. Bacteriol., 158, 79-83.
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.2.1.32 2-hydroxymuconic acid semialdehyde + NAD+ + H2O Cupriavidus necator dissimilatory meta-cleavage of catechols 2-hydroxymuconate + NADH + H+
-
 ?
1.2.1.32 2-hydroxymuconic acid semialdehyde + NAD+ + H2O Cupriavidus necator 345 dissimilatory meta-cleavage of catechols 2-hydroxymuconate + NADH + H+
-
 ?
1.2.1.32 2-hydroxymuconic acid semialdehyde + NAD+ + H2O Cupriavidus necator RA1012 dissimilatory meta-cleavage of catechols 2-hydroxymuconate + NADH + H+
-
 ?
4.1.1.77 4-Oxalocrotonate Cupriavidus necator but not p-cresol ?
-
 ?
4.1.1.77 4-Oxalocrotonate Cupriavidus necator strain 345: induced by growth with m-toluate, strain RA1012: induced by growth with p-cresol, but not m-toluate ?
-
 ?
4.1.1.77 4-Oxalocrotonate Cupriavidus necator 345 but not p-cresol ?
-
 ?
4.1.1.77 4-Oxalocrotonate Cupriavidus necator 345 strain 345: induced by growth with m-toluate, strain RA1012: induced by growth with p-cresol, but not m-toluate ?
-
 ?
4.1.1.77 4-Oxalocrotonate Cupriavidus necator RA1012 but not p-cresol ?
-
 ?
4.1.1.77 4-Oxalocrotonate Cupriavidus necator RA1012 strain 345: induced by growth with m-toluate, strain RA1012: induced by growth with p-cresol, but not m-toluate ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.2.1.32 Cupriavidus necator
-
 basonym Alcaligenes eutrophus, strain 335
-
4.1.1.77 Cupriavidus necator
-
-
-
4.1.1.77 Cupriavidus necator
-
 basonym Alcaligenes eutrophus
-
4.1.1.77 Cupriavidus necator 345
-
-
-
4.1.1.77 Cupriavidus necator RA1012
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.2.1.32 2-hydroxymuconic acid semialdehyde + NAD+ + H2O dissimilatory meta-cleavage of catechols Cupriavidus necator 2-hydroxymuconate + NADH + H+
-
 ?
1.2.1.32 2-hydroxymuconic acid semialdehyde + NAD+ + H2O dissimilatory meta-cleavage of catechols Cupriavidus necator 345 2-hydroxymuconate + NADH + H+
-
 ?
1.2.1.32 2-hydroxymuconic acid semialdehyde + NAD+ + H2O dissimilatory meta-cleavage of catechols Cupriavidus necator RA1012 2-hydroxymuconate + NADH + H+
-
 ?
4.1.1.77 4-Oxalocrotonate
-
 Cupriavidus necator 2-Oxopent-4-enoate + CO2
-
 ?
4.1.1.77 4-Oxalocrotonate
-
 Cupriavidus necator 345 2-Oxopent-4-enoate + CO2
-
 ?
4.1.1.77 4-Oxalocrotonate
-
 Cupriavidus necator RA1012 2-Oxopent-4-enoate + CO2
-
 ?
4.1.1.77 4-Oxalocrotonate but not p-cresol Cupriavidus necator ?
-
 ?
4.1.1.77 4-Oxalocrotonate strain 345: induced by growth with m-toluate, strain RA1012: induced by growth with p-cresol, but not m-toluate Cupriavidus necator ?
-
 ?
4.1.1.77 4-Oxalocrotonate but not p-cresol Cupriavidus necator 345 ?
-
 ?
4.1.1.77 4-Oxalocrotonate strain 345: induced by growth with m-toluate, strain RA1012: induced by growth with p-cresol, but not m-toluate Cupriavidus necator 345 ?
-
 ?
4.1.1.77 4-Oxalocrotonate but not p-cresol Cupriavidus necator RA1012 ?
-
 ?
4.1.1.77 4-Oxalocrotonate strain 345: induced by growth with m-toluate, strain RA1012: induced by growth with p-cresol, but not m-toluate Cupriavidus necator RA1012 ?
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
1.2.1.32 NAD+
-
 Cupriavidus necator