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Literature summary extracted from
- Biosynthesis of itaconic acid in Aspergillus terreus (1957), J. Biol. Chem., 226, 703-720.
General Stability
| EC Number | General Stability | Organism |
|---|---|---|
| 4.1.1.6 | no loss of activity after dialysis for 2 h at 0°C against 0.05 M phosphate buffer, pH 7. Inactivation after 15 h | Aspergillus terreus |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 4.1.1.6 | Cu2+ | - |
Aspergillus terreus |  |
| 4.1.1.6 | Fe2+ | - |
Aspergillus terreus | |
| 4.1.1.6 | Fluorocitrate | inhibits citrate decarboxylation, no inhibition of decarboxylation of cis-aconitate | Aspergillus terreus | |
| 4.1.1.6 | Hg2+ | - |
Aspergillus terreus | |
| 4.1.1.6 | L-Isocitric acid | competitive inhibition | Aspergillus terreus | |
| 4.1.1.6 | p-chloromercuribenzoate | - |
Aspergillus terreus | |
| 4.1.1.6 | trans-aconitate | slight inhibition of decarboxylation of citrate | Aspergillus terreus | |
| 4.1.1.6 | Zn2+ | - |
Aspergillus terreus | |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 4.1.1.6 | cis-aconitate | Aspergillus terreus | enzyme is involved in biosynthesis of itaconate | ? | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 4.1.1.6 | Aspergillus terreus | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 4.1.1.6 | - |
Aspergillus terreus |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 4.1.1.6 | mycelium | - |
Aspergillus terreus | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 4.1.1.6 | cis-aconitate | no activity with trans-aconitate | Aspergillus terreus | itaconate + CO2 | - |
? | |
| 4.1.1.6 | cis-aconitate | enzyme is involved in biosynthesis of itaconate | Aspergillus terreus | ? | - |
? | |
| 4.1.1.6 | citrate | - |
Aspergillus terreus | itaconate + CO2 | - |
? | |
| 4.1.1.6 | D-isocitrate | - |
Aspergillus terreus | itaconate + CO2 | - |
? | |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 4.1.1.6 | 5.6 | 6 | - |
Aspergillus terreus |
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