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Literature summary extracted from

  • Freist, W.; von der Haar, F.; Cramer, F.
    Isoleucyl-tRNA synthetase from baker's yeast (1981), Eur. J. Biochem., 119, 151-164.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
6.1.1.5 3'-deoxyadenosine i.e. cordycepin Saccharomyces cerevisiae
6.1.1.5 8-Aminoadenosine
-
 Saccharomyces cerevisiae
6.1.1.5 8-azidoadenosine 5'-triphosphate
-
 Saccharomyces cerevisiae
6.1.1.5 purineriboside i.e. nebularin Saccharomyces cerevisiae

Organism

EC Number Organism UniProt Comment Textmining
6.1.1.5 Saccharomyces cerevisiae
-
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
6.1.1.5 ATP + L-isoleucine + tRNAIle = AMP + diphosphate + L-isoleucyl-tRNAIle mechanism of aminoacylation in absence of diphosphatase is ordered ter-ter, in presence of diphosphatase random bi-uni uni-bi ping-pong Saccharomyces cerevisiae
a

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.1.1.5 ATP + L-isoleucine + tRNAIle
-
 Saccharomyces cerevisiae AMP + diphosphate + L-isoleucyl-tRNAIle
-
 ?
6.1.1.5 additional information Ile + ATP + enzyme/Ile-AMP-enzyme + diphosphate, isoleucine-dependent ATP-diphosphate exchange Saccharomyces cerevisiae ?
-
 ?