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Literature summary extracted from

  • White, E.L.; Arnett, G.; Secrist III, J.A.; Shannon, W.M.
    Characterization of S-adenosylmethionine decarboxylase induced by human cytomegalovirus infection (1994), Virus Res., 31, 255-263.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
4.1.1.50 putrescine stimulation Homo sapiens

General Stability

EC Number General Stability Organism
4.1.1.50 freezing inactivates Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.1.1.50 5'-Deoxy-5'-[(3-hydrazinopropyl)methylamino]adenosine
-
 Homo sapiens
4.1.1.50 additional information unaffected by divalent cations Homo sapiens
4.1.1.50 NaCl enzyme from infected cells is unaffected up to 0.8 M, 50% inhibition of the enzyme from uninfected cells at 0.45 M Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
4.1.1.50 0.146
-
 S-adenosyl-L-methionine enzyme from infected cells Homo sapiens
4.1.1.50 0.245
-
 S-adenosyl-L-methionine enzyme from uninfected cells Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
4.1.1.50 additional information unaffected by divalent cations Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.1.1.50 S-adenosyl-L-methionine Homo sapiens key enzyme in polyamine biosynthesis ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.1.1.50 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.1.1.50 lung MRC5, diploid, embryonic, uninfected or infected with cytomegalovirus Homo sapiens
-

Storage Stability

EC Number Storage Stability Organism
4.1.1.50 4°C, stable for up to 2 weeks Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.1.1.50 S-adenosyl-L-methionine
-
 Homo sapiens (5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2
-
 ?
4.1.1.50 S-adenosyl-L-methionine key enzyme in polyamine biosynthesis Homo sapiens ?
-
 ?

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
4.1.1.50 47
-
 10 min, 50% loss of activity Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
4.1.1.50 7.2 7.4
-
 Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
4.1.1.50 0.45
-
 NaCl inhibition of the enzyme from uninfected cells Homo sapiens
4.1.1.50 0.45
-
 NaCl enzyme from infected cells is unaffected up to 0.8 M Homo sapiens