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Literature summary extracted from

  • Anton, D.L.; Kutny, R.
    Mechanism of substrate inactivation of Escherichia coli S-adenosylmethionine decarboxylase (1987), Biochemistry, 26, 6444-6447.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
4.1.1.50 pyruvate contains pyruvate Escherichia coli

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.1.1.50 S-adenosyl-L-methionine substrate inactivation results in the conversion of the pyruvoyl group to an alanyl residue. The mechanism of inactivation involves the transamination of the nascent product to the pyruvoyl group, followed by the elimination of methylthioadenosine and the generation of a 2-propenal equivalent which can undergo a Michael addition to the enzyme Escherichia coli

Organism

EC Number Organism UniProt Comment Textmining
4.1.1.50 Escherichia coli
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-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.1.1.50 S-adenosyl-L-methionine
-
Escherichia coli (5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2
-
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