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Literature summary extracted from

  • Andreotti, G.; Cubellis, M.V.; di Palo, M.; Fessas, D.; Sannia, G.; Marino, G.
    Stability of a thermophilic TIM-barrel enzyme: indole-3-glycerol phosphate synthase from the thermophilic archaeon Sulfolobus solfataricus (1997), Biochem. J., 323, 259-264.
    View publication on PubMedView publication on EuropePMC

General Stability

EC Number General Stability Organism
4.1.1.48 guanidinium-induced denaturation. Unfolding mechanism closely approaches a two-state model at pH 7.0 and a more complex mechanism at pH 9.0 Saccharolobus solfataricus

Organism

EC Number Organism UniProt Comment Textmining
4.1.1.48 Saccharolobus solfataricus
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.1.1.48 1-(2-Carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
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 Saccharolobus solfataricus 1-(3-Indolyl)glycerol-3-phosphate + CO2 + H2O
-
 ?

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
4.1.1.48 additional information
-
 melting temperature is higher at alkaline that at neutral pH Saccharolobus solfataricus
4.1.1.48 80
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 first-order kinetic constant at pH 6.5, pH 8.0 and pH 9.5: 0.020 per min Saccharolobus solfataricus

pH Stability

EC Number pH Stability pH Stability Maximum Comment Organism
4.1.1.48 additional information
-
 melting temperature is higher at alkaline that at neutral pH Saccharolobus solfataricus