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Literature summary extracted from

  • De Verneuil, H.; Sassa, Sh.; Kappas, A.
    Purification and properties of uroporphyrinogen decarboxylase from human erythrocytes (1983), J. Biol. Chem., 258, 2454-2460.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.1.1.37 5,5'-dithiobis(2-nitrobenzoate)
-
 Homo sapiens
4.1.1.37 Cu2+ strong Homo sapiens
4.1.1.37 Fe2+ weak Homo sapiens
4.1.1.37 Hg2+ strong Homo sapiens
4.1.1.37 iodoacetamide
-
 Homo sapiens
4.1.1.37 NEM
-
 Homo sapiens
4.1.1.37 p-hydroxymercuribenzoate
-
 Homo sapiens
4.1.1.37 Pt2+ strong Homo sapiens
4.1.1.37 Sn2+ weak Homo sapiens
4.1.1.37 Zn2+ weak Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
4.1.1.37 0.00005
-
 5-COOH-porphyrinogen III
-
 Homo sapiens
4.1.1.37 0.00007
-
 5-COOH-porphyrinogen I
-
 Homo sapiens
4.1.1.37 0.00035
-
 7-COOH-porphyrinogen III
-
 Homo sapiens
4.1.1.37 0.0008
-
 Uroporphyrinogen I
-
 Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
4.1.1.37 46000
-
 1 * 46000, SDS-PAGE Homo sapiens
4.1.1.37 58000
-
 gel filtration Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
4.1.1.37 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
4.1.1.37
-
 Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.1.1.37 erythrocyte
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
4.1.1.37 0.17
-
-
 Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.1.1.37 5-COOH-porphyrinogen I
-
 Homo sapiens Coproporphyrinogen I + CO2
-
 ?
4.1.1.37 5-COOH-porphyrinogen III
-
 Homo sapiens Coproporphyrinogen III + CO2
-
 ?
4.1.1.37 7-COOH-porphyrinogen III
-
 Homo sapiens Coproporphyrinogen III + CO2
-
 ?
4.1.1.37 uroporphyrinogen I
-
 Homo sapiens coproporphyrinogen I + 4 CO2
-
 ?
4.1.1.37 Uroporphyrinogen III
-
 Homo sapiens Coproporphyrinogen III + 4 CO2
-
 ?

Subunits

EC Number Subunits Comment Organism
4.1.1.37 monomer 1 * 46000, SDS-PAGE Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
4.1.1.37 5.4
-
 5-COOH-porphyrinogen I as substrate Homo sapiens
4.1.1.37 6.2
-
 with uroporphyrinogen I as substrate Homo sapiens
4.1.1.37 6.8
-
 with uroporphyrinogen III or 5-COOH-porphyrinogen III as substrate Homo sapiens

pH Range

EC Number pH Minimum pH Maximum Comment Organism
4.1.1.37 5 6.6 pH 5.0: about 80% of maximal activity, pH 6.6: about 40% of maximal activity, 5-COOH-porphyrinogen I Homo sapiens
4.1.1.37 5.8 7.8 pH 5.8: about 60% of maximal activity, pH 7.8: about 55% of maximal activity, 5-COOH-porphyrinogen III Homo sapiens
4.1.1.37 5.8 7.4 pH 5.8: about 65% of maximal activity, pH 7.4: about 45% of maximal activity, uroporphyrinogen I Homo sapiens
4.1.1.37 6 7.2 pH 6.0: about 50% of maximal activity, pH 7.2: about 60% of maximal activity, uroporphyrinogen III Homo sapiens