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Literature summary extracted from

  • Weisiger, R.A.; Jakoby, W.B.
    Thiol S-methyltransferase (1981), Methods Enzymol., 77, 257-262.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.1.1.9 N-ethylmaleimide
-
 Rattus norvegicus
2.1.1.9 p-chloromercuribenzoate
-
 Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.1.1.9 additional information
-
 additional information
-
 Rattus norvegicus
2.1.1.9 0.00054
-
 4-Chlorothiophenol
-
 Rattus norvegicus
2.1.1.9 0.0011
-
 phenyl sulfide
-
 Rattus norvegicus
2.1.1.9 0.0028
-
 4-Nitrothiophenol
-
 Rattus norvegicus
2.1.1.9 0.012
-
 Diethylthiocarbamoyl sulfide
-
 Rattus norvegicus
2.1.1.9 0.043
-
 2-Thioacetanilide
-
 Rattus norvegicus
2.1.1.9 0.11
-
 2-Benzimidazole thiol
-
 Rattus norvegicus
2.1.1.9 0.19
-
 thioglycolic acid
-
 Rattus norvegicus
2.1.1.9 0.21
-
 L-cysteine methyl ester
-
 Rattus norvegicus
2.1.1.9 0.4
-
 N-acetyl-L-cysteine
-
 Rattus norvegicus
2.1.1.9 1
-
 6-Propyl-2-thiouracil
-
 Rattus norvegicus
2.1.1.9 1.2
-
 2-mercaptopropionic acid
-
 Rattus norvegicus
2.1.1.9 1.4
-
 1-methylimidazol-2-thiol
-
 Rattus norvegicus
2.1.1.9 1.6
-
 2,3-Dimercaptopropanol
-
 Rattus norvegicus
2.1.1.9 4.7
-
 3-mercaptopropionic acid methyl ester
-
 Rattus norvegicus
2.1.1.9 8.1
-
 2-mercaptoethanol
-
 Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.1.1.9 microsome
-
 Rattus norvegicus
-
-
2.1.1.9 soluble in extracts of liver, kidney, intestine and spleen Rattus norvegicus
-
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.1.1.9 28000
-
 1 * 28000, SDS-PAGE Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.1.9 additional information Rattus norvegicus role in detoxification of hydrogen sulfide that is generated by the colonic flora ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.9 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.1.1.9
-
 Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.1.1.9 intestine
-
 Rattus norvegicus
-
2.1.1.9 kidney
-
 Rattus norvegicus
-
2.1.1.9 liver
-
 Rattus norvegicus
-
2.1.1.9 spleen
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.9 1-methylimidazole-2-thiol + S-adenosyl-L-methionine
-
 Rattus norvegicus 1-methyl-2-(methylthio)-1H-imidazole + S-adenosyl-L-homocysteine
-
 ?
2.1.1.9 2,3-dimercaptopropanol + S-adenosyl-L-methionine
-
 Rattus norvegicus ? + S-adenosyl-L-homocysteine
-
 ?
2.1.1.9 2-benzimidazole thiol + S-adenosyl-L-methionine
-
 Rattus norvegicus ? + S-adenosyl-L-homocysteine
-
 ?
2.1.1.9 2-mercaptopropionic acid + S-adenosyl-L-methionine
-
 Rattus norvegicus S-methyl-2-mercaptopropionic acid + S-adenosyl-L-homocysteine
-
 ?
2.1.1.9 2-thioacetanilide + S-adenosyl-L-methionine
-
 Rattus norvegicus S-methyl-2-thioacetanilide + S-adenosyl-L-homocysteine
-
 ?
2.1.1.9 3-mercaptopropionic acid methyl ester + S-adenosyl-L-methionine
-
 Rattus norvegicus S-methyl-3-mercaptopropionic acid methyl ester + S-adenosyl-L-homocysteine
-
 ?
2.1.1.9 4-chlorothiophenol + S-adenosyl-L-methionine
-
 Rattus norvegicus 4-chloro-S-methylphenylmercaptan + S-adenosyl-L-homocysteine
-
 ?
2.1.1.9 4-nitrothiophenol + S-adenosyl-L-methionine
-
 Rattus norvegicus 4-nitro-S-methylphenylmercaptan + S-adenosyl-L-homocysteine
-
 ?
2.1.1.9 6-propyl-2-thiouracil + S-adenosyl-L-methionine
-
 Rattus norvegicus 6-propyl-S-methyl-2-thiouracil + S-adenosyl-L-homocysteine
-
 ?
2.1.1.9 diethylthiocarbamoyl sulfide + S-adenosyl-L-methionine
-
 Rattus norvegicus ? + S-adenosyl-L-homocysteine
-
 ?
2.1.1.9 L-cysteine methyl ester + S-adenosyl-L-methionine
-
 Rattus norvegicus S-methyl-L-cysteine methyl ester + S-adenosyl-L-homocysteine
-
 ?
2.1.1.9 mercaptoacetic acid + S-adenosyl-L-methionine
-
 Rattus norvegicus S-methylmercaptoacetic acid + S-adenosyl-L-homocysteine
-
 ?
2.1.1.9 additional information role in detoxification of hydrogen sulfide that is generated by the colonic flora Rattus norvegicus ?
-
 ?
2.1.1.9 N-acetyl-L-cysteine + S-adenosyl-L-methionine
-
 Rattus norvegicus N-acetyl-S-methyl-L-cysteine + S-adenosyl-L-homocysteine
-
 ?
2.1.1.9 phenyl sulfide + S-adenosyl-L-methionine
-
 Rattus norvegicus ? + S-adenosyl-L-homocysteine
-
 ?

Subunits

EC Number Subunits Comment Organism
2.1.1.9 monomer 1 * 28000, SDS-PAGE Rattus norvegicus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.1.1.9 37
-
 assay at Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.1.1.9 7.5
-
-
 Rattus norvegicus

pH Range

EC Number pH Minimum pH Maximum Comment Organism
2.1.1.9 6.6 8.6 about 50% of maximum activity at pH 6.6 and pH 8.6 Rattus norvegicus