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Literature summary extracted from

  • Borchardt, R.T.; Matuszewska, B.
    S-adenosylmethionine dependent transmethylation of histamine: Purification and partial characterization of guinea pig brain and rat kidney histamine N-methyltransferase (1985), Adv. Biosci., 51, 163-172.
No PubMed abstract available

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.1.1.8 S-adenosylhomocysteine
-
 Cavia porcellus
2.1.1.8 S-adenosylhomocysteine
-
 Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.8 Cavia porcellus
-
-
-
2.1.1.8 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.1.1.8
-
 Cavia porcellus
2.1.1.8
-
 Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.1.1.8 brain
-
 Cavia porcellus
-
2.1.1.8 brain
-
 Rattus norvegicus
-
2.1.1.8 kidney
-
 Cavia porcellus
-
2.1.1.8 kidney
-
 Rattus norvegicus
-

Storage Stability

EC Number Storage Stability Organism
2.1.1.8 -80°C, 3 months Cavia porcellus
2.1.1.8 -80°C, 3 months Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.8 S-adenosyl-L-methionine + histamine
-
 Cavia porcellus S-adenosyl-L-homocysteine + Ntau-methylhistamine
-
 ?
2.1.1.8 S-adenosyl-L-methionine + histamine
-
 Rattus norvegicus S-adenosyl-L-homocysteine + Ntau-methylhistamine
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.1.1.8 7.5
-
 2 optima at pH 7.5 and pH 9.0, brain enzyme Cavia porcellus
2.1.1.8 8.5 9 kidney enzyme Rattus norvegicus
2.1.1.8 9
-
-
 Cavia porcellus
2.1.1.8 9
-
 kidney Rattus norvegicus