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Literature summary extracted from

  • Thithapandha, A.; Cohn, V.H.
    Brain histamine N-methyltransferase purification, mechanism of action, and inhibition by drugs (1978), Biochem. Pharmacol., 27, 263-271.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.1.1.8 Methylhistamine
-
 Cavia porcellus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.1.1.8 additional information
-
 additional information
-
 Cavia porcellus
2.1.1.8 0.043
-
 histamine
-
 Cavia porcellus

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.8 Cavia porcellus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.1.1.8
-
 Cavia porcellus

Reaction

EC Number Reaction Comment Organism Reaction ID
2.1.1.8 S-adenosyl-L-methionine + histamine = S-adenosyl-L-homocysteine + Ntau-methylhistamine 2 half-reactions in a ping pong mechanism with the intermediate formation of a methylated enzyme Cavia porcellus
a

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.1.1.8 brain
-
 Cavia porcellus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.8 S-adenosyl-L-methionine + histamine highly specific for histamine Cavia porcellus S-adenosyl-L-homocysteine + Ntau-methylhistamine
-
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