Literature summary extracted from

Beaven, M.A.; Roderick, N.B.
Impromidine, a potent inhibitor of histamine methyltransferase (HMT) and diamine oxidase (DAO) (1980), Biochem. Pharmacol., 29, 2897-2900.

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
2.1.1.8	amodiaquine	-	Rattus norvegicus
2.1.1.8	d-Chlorpheniramine	-	Rattus norvegicus
2.1.1.8	Dimaprit	-	Rattus norvegicus
2.1.1.8	ethylamine	-	Rattus norvegicus
2.1.1.8	Impromidine	competitive, reversible	Rattus norvegicus
2.1.1.8	SKF 91488	-	Rattus norvegicus

Organism

EC Number	Organism	UniProt	Comment	Textmining
2.1.1.8	Rattus norvegicus	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
2.1.1.8	kidney	-	Rattus norvegicus	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2.1.1.8	S-adenosyl-L-methionine + histamine	-	Rattus norvegicus	S-adenosyl-L-homocysteine + Ntau-methylhistamine	-	?

Ki Value [mM]

EC Number	Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
2.1.1.8	0.00005	-	Amodiaquin	-	Rattus norvegicus
2.1.1.8	0.0007	-	d-Chlorpheniramine	-	Rattus norvegicus
2.1.1.8	0.001	-	SKF 91488	-	Rattus norvegicus
2.1.1.8	0.008	-	Dimaprit	-	Rattus norvegicus

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Release 2023.1 (January 2023)