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Literature summary extracted from

  • Ball, P.; Knuppen, R.; Haupt, M.; Breuer, H.
    Kinetic properties of a soluble catechol O-methyltransferase of human liver (1972), Eur. J. Biochem., 26, 560-569.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.1.1.6 cysteine required Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.1.1.6 2-Hydroxyestradiol-17beta 3-methyl ether product inhibition Homo sapiens
2.1.1.6 2-methoxyestradiol-17beta product inhibition Homo sapiens
2.1.1.6 Mg2+ required for activity Homo sapiens
2.1.1.6 additional information substrate inhibition is dependent on the concentration of S-adenosylmethionine and MgCl2 Homo sapiens
2.1.1.6 S-adenosyl-L-homocysteine
-
 Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.1.1.6 0.014
-
 2-hydroxyestradiol-17beta
-
 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.1.1.6 soluble
-
 Homo sapiens
-
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.1.1.6 Mg2+ required Homo sapiens
2.1.1.6 Mn2+
-
 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.6 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.1.1.6 liver
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.6 2-hydroxyestradiol-17beta + S-adenosyl-L-methionine
-
 Homo sapiens 2-methoxyestradiol-17beta + 2-hydroxyestradiol-17beta methyl ether + S-adenosyl-L-homocysteine
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.1.1.6 42
-
 2-hydroxyestradiol-17beta Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.1.1.6 6.8 8.4 leads to maximal formation of 2-methoxyestradiol-17beta Homo sapiens
2.1.1.6 9.2
-
 leads to maximal formation of 2- and 3-monomethyl ether Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.1.1.6 0.039
-
 S-adenosyl-L-homocysteine
-
 Homo sapiens