Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Shapiro, S.K.
    S-Adenosylmethionine:L-homocysteine S-methyltransferase (Saccharomyces cerevisiae) (1971), Methods Enzymol., 17B, 400-405.
No PubMed abstract available

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.1.1.10 2-mercaptoethanol increases activity at low substrate concentrations Saccharomyces cerevisiae

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.1.1.10 L-methionine no inhibition with D-isomer; product inhibition Saccharomyces cerevisiae
2.1.1.10 N-Hydroxymethyl-DL-methionine
-
 Saccharomyces cerevisiae
2.1.1.10 S-adenosyl-L-homocysteine product inhibition Saccharomyces cerevisiae

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.1.1.10 Cd2+ activating Saccharomyces cerevisiae
2.1.1.10 Zn2+ activating Saccharomyces cerevisiae

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.1.1.10 30000
-
 from sedimentation coefficient Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.1.10 S-adenosyl-L-methionine + L-homocysteine Rattus norvegicus
-
 S-adenosyl-L-homocysteine + L-methionine
-
 ?
2.1.1.10 S-adenosyl-L-methionine + L-homocysteine Saccharomyces cerevisiae
-
 S-adenosyl-L-homocysteine + L-methionine
-
 ?
2.1.1.10 S-adenosyl-L-methionine + L-homocysteine Klebsiella aerogenes
-
 S-adenosyl-L-homocysteine + L-methionine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.10 Klebsiella aerogenes
-
-
-
2.1.1.10 Rattus norvegicus
-
-
-
2.1.1.10 Saccharomyces cerevisiae
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.1.1.10
-
 Saccharomyces cerevisiae

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.1.1.10 1.37
-
 purified enzyme, S-adenosyl-L-methionine as methyl donor Saccharomyces cerevisiae

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.10 S-adenosyl-L-ethionine + L-homocysteine
-
 Saccharomyces cerevisiae S-adenosyl-L-homocysteine + L-ethionine
-
 ?
2.1.1.10 S-adenosyl-L-methionine + D-homocysteine
-
 Saccharomyces cerevisiae ?
-
 ?
2.1.1.10 S-adenosyl-L-methionine + L-homocysteine
-
 Rattus norvegicus S-adenosyl-L-homocysteine + L-methionine
-
 ?
2.1.1.10 S-adenosyl-L-methionine + L-homocysteine
-
 Saccharomyces cerevisiae S-adenosyl-L-homocysteine + L-methionine
-
 ?
2.1.1.10 S-adenosyl-L-methionine + L-homocysteine
-
 Klebsiella aerogenes S-adenosyl-L-homocysteine + L-methionine
-
 ?
2.1.1.10 S-adenosyl-L-methionine + L-homocysteine thiolactone
-
 Saccharomyces cerevisiae ?
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.1.1.10 7.5 8
-
 Saccharomyces cerevisiae