Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Johansson, M.J.O.; Bystr๖m, A.S.
    Dual function of the tRNA(m5U54)methyltransferase in tRNA maturation (2002), RNA, 8, 324-335.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.1.1.35 enzyme is encoded by the nonessential TRM2 gene Saccharomyces cerevisiae

Protein Variants

EC Number Protein Variants Comment Organism
2.1.1.35 C521A mutant without methyltransferase activity, putative nucleophilic Cys-521 may be involved in Cys-U54 bond formation Saccharomyces cerevisiae
2.1.1.35 G428D mutant without methyltransferase activity, G-428 is located at the presumed S-adenosyl-L-methionine binding site Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.1.35 S-adenosyl-L-methionine + uridine54 in tRNA Saccharomyces cerevisiae role per se in tRNA maturation, stabilization of tRNA, early event in tRNA maturation: intron-containing pre-tRNAs contain m5U S-adenosyl-L-homocysteine + 5-methyluridine54 in tRNA
-
?

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.35 Saccharomyces cerevisiae
-
several strains
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.35 additional information absence of TRM2 gene encoding enzyme in strains with mutant forms of tRNASerCGA decreases the stability of tRNASerCGA and induces lethality Saccharomyces cerevisiae additional information
-
?
2.1.1.35 S-adenosyl-L-methionine + uridine54 in tRNA methylation of U54 Saccharomyces cerevisiae S-adenosyl-L-homocysteine + 5-methyluridine54 in tRNA nearly all tRNAs contain m5U54, initiators excluded ?
2.1.1.35 S-adenosyl-L-methionine + uridine54 in tRNA role per se in tRNA maturation, stabilization of tRNA, early event in tRNA maturation: intron-containing pre-tRNAs contain m5U Saccharomyces cerevisiae S-adenosyl-L-homocysteine + 5-methyluridine54 in tRNA
-
?

Cofactor

EC Number Cofactor Comment Organism Structure
2.1.1.35 S-adenosyl-L-methionine
-
Saccharomyces cerevisiae