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Literature summary extracted from

  • Kim, Y.H.; Joo, I.
    Arylamine N-methyltransferase and thiol methyltransferase activities in cholestatic rat liver induced by common bile duct ligation (2001), Exp. Mol. Med., 33, 23-28.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.1.1.49 additional information biosynthesis of enzyme is induced in response to obstructive jaundice Rattus norvegicus

Application

EC Number Application Comment Organism
2.1.1.9 medicine enzyme activity in cholestatic liver Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.1.1.49 28.3
-
 tryptamine mitochondrial enzyme, cholestatic liver, S-adenosyl-L-methionine Rattus norvegicus
2.1.1.49 32.5
-
 tryptamine mitochondrial enzyme, control liver, S-adenosyl-L-methionine Rattus norvegicus
2.1.1.49 34.1
-
 tryptamine microsomal enzyme, cholestatic liver, S-adenosyl-L-methionine Rattus norvegicus
2.1.1.49 35.6
-
 tryptamine microsomal enzyme, control liver, S-adenosyl-L-methionine Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.1.1.49 cytosol liver Rattus norvegicus 5829
-
2.1.1.49 membrane hepatic membrane-bound enzyme Rattus norvegicus 16020
-
2.1.1.49 microsome liver Rattus norvegicus
-
-
2.1.1.49 mitochondrion liver Rattus norvegicus 5739
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.1.49 S-adenosyl-L-methionine + an amine Rattus norvegicus xenobiotic biotransforming enzyme, enzyme is leaked easily into the blood stream due to an increased membrane permeability of hepatocytes caused by cholestasis S-adenosyl-L-homocysteine + an N-methylamine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.9 Rattus norvegicus
-
-
-
2.1.1.49 Rattus norvegicus
-
 Sprague-Dawley strain male rats
-
2.1.1.49 Rattus norvegicus
-
 rats with common bile duct ligation and obstructive jaundice respectively
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.1.1.49 brain
-
 Rattus norvegicus
-
2.1.1.49 heart
-
 Rattus norvegicus
-
2.1.1.49 liver investigation of enzyme in cholestatic liver, induced by common bile duct ligation for a period of 42 days Rattus norvegicus
-
2.1.1.49 lung
-
 Rattus norvegicus
-
2.1.1.49 salivary gland
-
 Rattus norvegicus
-
2.1.1.49 serum investigation of enzyme in serum, after common bile duct ligation for a period of 42 days Rattus norvegicus
-
2.1.1.49 small intestine
-
 Rattus norvegicus
-
2.1.1.49 stomach
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.1.1.49 additional information
-
 specific activities of serum, control and cholestatic liver in cytosolic, mitochondrial and microsomal preparations for 0.5, 1, 2, 3, 7, 14, 28 and 42 days after common bile duct ligation, activities of mitochondrial and microsomal enzyme in cholestatic liver and of serum enzyme increase after common bile duct ligation, Vmax-values Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.49 S-adenosyl-L-methionine + an amine xenobiotic biotransforming enzyme, enzyme is leaked easily into the blood stream due to an increased membrane permeability of hepatocytes caused by cholestasis Rattus norvegicus S-adenosyl-L-homocysteine + an N-methylamine
-
 ?
2.1.1.49 S-adenosyl-L-methionine + tryptamine S-adenosyl-L-methionine-dependent enzyme Rattus norvegicus S-adenosyl-L-homocysteine + alpha-N-methyltryptamine
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.1.1.49 37
-
 assay at Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
2.1.1.49 S-adenosyl-L-methionine
-
 Rattus norvegicus