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Literature summary extracted from

  • Hsu, L.L.; Mandell, A.J.
    Multiple N-methyltransferases for aromatic alkylamines in brain (1973), Life Sci., 13, 847-858.
    View publication on PubMed

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.1.1.49 6.25
-
 beta-phenylethylamine 5-methyltetrahydrofolate as methyl donor Rattus norvegicus
2.1.1.49 8.3
-
 tryptamine 5-methyltetrahydrofolate as methyl donor Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.49 Rattus norvegicus
-
 Sprague-Dawley strain male rats
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.1.1.49 partial Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.1.1.49 brain
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.1.1.49 0.00000038
-
 beta-phenylethylamine + S-adenosyl-L-methionine Rattus norvegicus
2.1.1.49 0.00000118
-
 tryptamine + S-adenosyl-L-methionine Rattus norvegicus
2.1.1.49 0.000065
-
 beta-phenylethylamine + 5-methyltetrahydrofolate Rattus norvegicus
2.1.1.49 0.000198
-
 tryptamine + 5-methyltetrahydrofolate Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.49 S-adenosyl-L-methionine + alpha-N-methyltryptamine
-
 Rattus norvegicus S-adenosyl-L-homocysteine + alpha,alpha-N,N-dimethyltryptamine N,N-dimethyltryptamine as product ?
2.1.1.49 S-adenosyl-L-methionine + beta-phenylethylamine 5-methyltetrahydrofolate can replace S-adenosyl-L-methionine as methyl donor Rattus norvegicus ?
-
 ?
2.1.1.49 S-adenosyl-L-methionine + tryptamine two N-methyltransferases, non-specific or specific for tryptamine, 5-methyltetrahydrofolate can replace S-adenosyl-L-methionine as methyl donor Rattus norvegicus S-adenosyl-L-homocysteine + alpha-N-methyltryptamine
-
 ?
2.1.1.49 S-adenosyl-L-methionine + tryptamine i.e. 3-[2-aminoethyl] indole, best substrate, two N-methyltransferases: A and B, non-specific Rattus norvegicus S-adenosyl-L-homocysteine + alpha-N-methyltryptamine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.1.1.49 aromatic alkylamine-N-methyltransferase
-
 Rattus norvegicus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.1.1.49 37
-
 assay at Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.1.1.49 6.5 7 5-methyltetrahydrofolate as donor Rattus norvegicus
2.1.1.49 7.9
-
 S-adenosyl-L-methionine as donor Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
2.1.1.49 S-adenosyl-L-methionine
-
 Rattus norvegicus