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Literature summary extracted from

  • Taylor, R.T.; Weissbach, H.
    N5-Methyltetrahydrofolate-homocysteine methyltransferases (1973), The Enzymes, 3rd Ed. (Boyer, P. D. , ed. ), 9, 121-165.
No PubMed abstract available

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.1.1.14 EDTA
-
 Auxenochlorella pyrenoidosa
2.1.1.14 EDTA
-
 Escherichia coli
2.1.1.14 EDTA
-
 Klebsiella aerogenes
2.1.1.14 EDTA
-
 Neurospora crassa
2.1.1.14 EDTA
-
 Saccharomyces cerevisiae
2.1.1.14 EDTA
-
 Salmonella enterica subsp. enterica serovar Typhimurium

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.1.1.14 Ca2+ can replace Mg2+ Salmonella enterica subsp. enterica serovar Typhimurium
2.1.1.14 Ca2+ can replace Mg2+ Neurospora crassa
2.1.1.14 Ca2+ can replace Mg2+ Klebsiella aerogenes
2.1.1.14 Ca2+ can replace Mg2+ Auxenochlorella pyrenoidosa
2.1.1.14 Mg2+ stimulates Salmonella enterica subsp. enterica serovar Typhimurium
2.1.1.14 Mg2+ stimulates Escherichia coli
2.1.1.14 Mg2+ stimulates Neurospora crassa
2.1.1.14 Mg2+ stimulates Klebsiella aerogenes
2.1.1.14 Mg2+ stimulates Auxenochlorella pyrenoidosa
2.1.1.14 Mg2+ no stimulation Saccharomyces cerevisiae
2.1.1.14 phosphate
-
 Salmonella enterica subsp. enterica serovar Typhimurium
2.1.1.14 phosphate
-
 Escherichia coli
2.1.1.14 phosphate
-
 Saccharomyces cerevisiae
2.1.1.14 phosphate
-
 Neurospora crassa
2.1.1.14 phosphate
-
 Klebsiella aerogenes
2.1.1.14 phosphate
-
 Auxenochlorella pyrenoidosa

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.1.1.14 50800
-
 x * 50800, equilibrium sedimentation of carboxymethylated enzyme in 5 M guanidine-HCl Escherichia coli
2.1.1.14 75000
-
 gel filtration, sedimentation data Saccharomyces cerevisiae
2.1.1.14 84000
-
 equilibrium ultracentrifugation Escherichia coli

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.14 Auxenochlorella pyrenoidosa
-
-
-
2.1.1.14 Escherichia coli
-
-
-
2.1.1.14 Klebsiella aerogenes
-
-
-
2.1.1.14 Neurospora crassa
-
-
-
2.1.1.14 Saccharomyces cerevisiae
-
-
-
2.1.1.14 Salmonella enterica subsp. enterica serovar Typhimurium
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.14 additional information monoglutamate analog not used Salmonella enterica subsp. enterica serovar Typhimurium ?
-
 ?
2.1.1.14 additional information monoglutamate analog not used Escherichia coli ?
-
 ?
2.1.1.14 additional information monoglutamate analog not used Saccharomyces cerevisiae ?
-
 ?
2.1.1.14 additional information monoglutamate analog not used Neurospora crassa ?
-
 ?
2.1.1.14 additional information monoglutamate analog not used Klebsiella aerogenes ?
-
 ?
2.1.1.14 additional information monoglutamate analog not used Auxenochlorella pyrenoidosa ?
-
 ?

Subunits

EC Number Subunits Comment Organism
2.1.1.14 ? x * 50800, equilibrium sedimentation of carboxymethylated enzyme in 5 M guanidine-HCl Escherichia coli

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.1.1.14 6.6 7.6
-
 Saccharomyces cerevisiae
2.1.1.14 7.5 7.8
-
 Escherichia coli

Cofactor

EC Number Cofactor Comment Organism Structure
2.1.1.14 additional information vitamin-B12 independent enzyme Salmonella enterica subsp. enterica serovar Typhimurium
2.1.1.14 additional information vitamin-B12 independent enzyme Escherichia coli
2.1.1.14 additional information vitamin-B12 independent enzyme Saccharomyces cerevisiae
2.1.1.14 additional information vitamin-B12 independent enzyme Neurospora crassa
2.1.1.14 additional information vitamin-B12 independent enzyme Klebsiella aerogenes
2.1.1.14 additional information vitamin-B12 independent enzyme Auxenochlorella pyrenoidosa