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Mouse liver nicotinamide N-methyltransferase pharmacogenetics: biochemical properties and variation in activity among inbred strains

Scheller, T.; Orgacka, H.; Szumlanski, C.L.; Weinshilboum, R.M.; Pharmacogenetics 6, 43-53 (1996)

Data extracted from this reference:

KM Value [mM]
EC Number
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
2.1.1.1
0.0065
-
S-adenosyl-L-methionine
-
Mus musculus
2.1.1.1
0.37
-
nicotinamide
-
Mus musculus
Localization
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
2.1.1.1
cytosol
-
Mus musculus
5829
-
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
2.1.1.1
Mus musculus
-
C57BL/6J
-
2.1.1.1
Mus musculus C57/BL6J
-
C57BL/6J
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
2.1.1.1
liver
-
Mus musculus
-
Specific Activity [micromol/min/mg]
EC Number
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
2.1.1.1
additional information
-
activity in male animals of different inbred strains
Mus musculus
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.1.1.1
S-adenosyl-L-methionine + nicotinamide
-
441258
Mus musculus
S-adenosyl-L-homocysteine + 1-methylnicotinamide
-
-
-
-
2.1.1.1
S-adenosyl-L-methionine + nicotinamide
-
441258
Mus musculus C57/BL6J
S-adenosyl-L-homocysteine + 1-methylnicotinamide
-
-
-
-
pH Optimum
EC Number
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
2.1.1.1
7.4
-
-
Mus musculus
KM Value [mM] (protein specific)
EC Number
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
2.1.1.1
0.0065
-
S-adenosyl-L-methionine
-
Mus musculus
2.1.1.1
0.37
-
nicotinamide
-
Mus musculus
Localization (protein specific)
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
2.1.1.1
cytosol
-
Mus musculus
5829
-
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
2.1.1.1
liver
-
Mus musculus
-
Specific Activity [micromol/min/mg] (protein specific)
EC Number
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
2.1.1.1
additional information
-
activity in male animals of different inbred strains
Mus musculus
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.1.1.1
S-adenosyl-L-methionine + nicotinamide
-
441258
Mus musculus
S-adenosyl-L-homocysteine + 1-methylnicotinamide
-
-
-
-
2.1.1.1
S-adenosyl-L-methionine + nicotinamide
-
441258
Mus musculus C57/BL6J
S-adenosyl-L-homocysteine + 1-methylnicotinamide
-
-
-
-
pH Optimum (protein specific)
EC Number
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
2.1.1.1
7.4
-
-
Mus musculus