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Literature summary extracted from

  • Scandurra, R.; Barboni, E.; Granata, F.; Pensa, B.; Costa, M.
    Pantothenoylcysteine-4'-phosphate decarboxylase from horse liver (1974), Eur. J. Biochem., 49, 1-9.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
4.1.1.36 2-mercaptoethanol increases activity Equus caballus
4.1.1.36 cysteine
-
 Rattus norvegicus
4.1.1.36 cysteine increases activity Equus caballus
4.1.1.36 DTT increases activity Equus caballus

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.1.1.36 4,4-Bis(dimethylaminodiphenylcarbinol)
-
 Rattus norvegicus
4.1.1.36 hydroxylamine
-
 Equus caballus
4.1.1.36 iodoacetamide
-
 Equus caballus
4.1.1.36 NaBH4
-
 Equus caballus
4.1.1.36 phenylhydrazine
-
 Equus caballus
4.1.1.36 pyridoxal 5'-phosphate
-
 Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
4.1.1.36 1.43
-
 4-phosphopantothenoyl-L-Cys
-
 Equus caballus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
4.1.1.36 intracellular not bound to any cellular structure Equus caballus 5622
-

Organism

EC Number Organism UniProt Comment Textmining
4.1.1.36 Bos taurus
-
-
-
4.1.1.36 Equus caballus
-
-
-
4.1.1.36 Oryctolagus cuniculus
-
-
-
4.1.1.36 Rattus norvegicus
-
-
-
4.1.1.36 Sus scrofa
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
4.1.1.36
-
 Equus caballus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.1.1.36 heart
-
 Sus scrofa
-
4.1.1.36 heart
-
 Bos taurus
-
4.1.1.36 heart
-
 Equus caballus
-
4.1.1.36 kidney
-
 Rattus norvegicus
-
4.1.1.36 kidney
-
 Sus scrofa
-
4.1.1.36 kidney
-
 Bos taurus
-
4.1.1.36 kidney
-
 Oryctolagus cuniculus
-
4.1.1.36 kidney
-
 Equus caballus
-
4.1.1.36 liver
-
 Rattus norvegicus
-
4.1.1.36 liver
-
 Sus scrofa
-
4.1.1.36 liver
-
 Bos taurus
-
4.1.1.36 liver
-
 Oryctolagus cuniculus
-
4.1.1.36 liver
-
 Equus caballus
-
4.1.1.36 muscle
-
 Sus scrofa
-
4.1.1.36 muscle
-
 Bos taurus
-
4.1.1.36 muscle
-
 Equus caballus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
4.1.1.36 0.089
-
-
 Equus caballus

Storage Stability

EC Number Storage Stability Organism
4.1.1.36 stable for at least 2 months if frozen as diluted solution, less than 1 mg/ml, or concentrated solution, 1-10 mg/ml Equus caballus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.1.1.36 N-((R)-4-Phosphopantothenoyl)-L-Cys
-
 Rattus norvegicus Pantotheine 4-phosphate + CO2
-
 ?
4.1.1.36 N-((R)-4-Phosphopantothenoyl)-L-Cys
-
 Sus scrofa Pantotheine 4-phosphate + CO2
-
 ?
4.1.1.36 N-((R)-4-Phosphopantothenoyl)-L-Cys
-
 Bos taurus Pantotheine 4-phosphate + CO2
-
 ?
4.1.1.36 N-((R)-4-Phosphopantothenoyl)-L-Cys
-
 Oryctolagus cuniculus Pantotheine 4-phosphate + CO2
-
 ?
4.1.1.36 N-((R)-4-Phosphopantothenoyl)-L-Cys specific for Equus caballus Pantotheine 4-phosphate + CO2
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
4.1.1.36 7.6
-
-
 Equus caballus

pH Range

EC Number pH Minimum pH Maximum Comment Organism
4.1.1.36 6 9.5 pH 9.5: 75% of optimal activity, pH 6: 23% of optimal activity Equus caballus