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Literature summary extracted from

  • Brown, G.M.
    The metabolism of pantothenic acid (1959), J. Biol. Chem., 234, 370-378.
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.1.33 cytosol
-
 Lactiplantibacillus plantarum 5829
-
2.7.1.33 cytosol
-
 Escherichia coli 5829
-
2.7.1.33 cytosol
-
 Rattus norvegicus 5829
-
2.7.1.33 cytosol
-
 Saccharomyces cerevisiae 5829
-
2.7.1.33 cytosol
-
 Morganella morganii 5829
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.1.33 Mg2+
-
 Lactiplantibacillus plantarum
2.7.1.33 Mg2+
-
 Escherichia coli
2.7.1.33 Mg2+
-
 Rattus norvegicus
2.7.1.33 Mg2+
-
 Saccharomyces cerevisiae
2.7.1.33 Mg2+
-
 Morganella morganii

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.33 ATP + D-pantothenate Lactiplantibacillus plantarum
-
 ADP + D-4'-phosphopantothenate
-
 ?
2.7.1.33 ATP + D-pantothenate Escherichia coli
-
 ADP + D-4'-phosphopantothenate
-
 ?
2.7.1.33 ATP + D-pantothenate Rattus norvegicus
-
 ADP + D-4'-phosphopantothenate
-
 ?
2.7.1.33 ATP + D-pantothenate Saccharomyces cerevisiae
-
 ADP + D-4'-phosphopantothenate
-
 ?
2.7.1.33 ATP + D-pantothenate Morganella morganii
-
 ADP + D-4'-phosphopantothenate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.33 Escherichia coli
-
-
-
2.7.1.33 Lactiplantibacillus plantarum
-
-
-
2.7.1.33 Morganella morganii
-
-
-
2.7.1.33 no activity in Lactobacillus helveticus
-
-
-
2.7.1.33 no activity in Neurospora crassa
-
-
-
2.7.1.33 Rattus norvegicus
-
-
-
2.7.1.33 Saccharomyces cerevisiae
-
-
-
4.1.1.36 Escherichia coli
-
-
-
4.1.1.36 Morganella morganii
-
-
-
4.1.1.36 Rattus norvegicus
-
-
-
6.3.2.5 Bacteria
-
-
-
6.3.2.5 Escherichia coli
-
-
-
6.3.2.5 Mammalia
-
-
-
6.3.2.5 Morganella morganii
-
-
-
6.3.2.5 no activity in Lactobacillus arabinosus
-
-
-
6.3.2.5 no activity in Lactobacillus helveticus
-
-
-
6.3.2.5 no activity in Saccharomyces cerevisiae
-
-
-
6.3.2.5 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.1.33 liver Saccharomyces cerevisiae
2.7.1.33 partial Rattus norvegicus
2.7.1.33 partial Saccharomyces cerevisiae

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.33 kidney
-
 Rattus norvegicus
-
2.7.1.33 liver
-
 Rattus norvegicus
-
4.1.1.36 kidney
-
 Rattus norvegicus
-
4.1.1.36 liver
-
 Rattus norvegicus
-
6.3.2.5 kidney
-
 Rattus norvegicus
-
6.3.2.5 liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.33 ATP + D-pantothenate
-
 Lactiplantibacillus plantarum ADP + D-4'-phosphopantothenate
-
 ?
2.7.1.33 ATP + D-pantothenate
-
 Escherichia coli ADP + D-4'-phosphopantothenate
-
 ?
2.7.1.33 ATP + D-pantothenate
-
 Rattus norvegicus ADP + D-4'-phosphopantothenate
-
 ?
2.7.1.33 ATP + D-pantothenate
-
 Saccharomyces cerevisiae ADP + D-4'-phosphopantothenate
-
 ?
2.7.1.33 ATP + D-pantothenate
-
 Morganella morganii ADP + D-4'-phosphopantothenate
-
 ?
4.1.1.36 N-((R)-4-Phosphopantothenoyl)-L-Cys
-
 Escherichia coli Pantotheine 4-phosphate + CO2
-
 ?
4.1.1.36 N-((R)-4-Phosphopantothenoyl)-L-Cys
-
 Rattus norvegicus Pantotheine 4-phosphate + CO2
-
 ?
4.1.1.36 N-((R)-4-Phosphopantothenoyl)-L-Cys
-
 Morganella morganii Pantotheine 4-phosphate + CO2
-
 ?
6.3.2.5 ATP + (R)-4'-phosphopantothenate + 2-aminoethanethiol disulfide
-
 Rattus norvegicus ?
-
 ?
6.3.2.5 ATP + (R)-4'-phosphopantothenate + 2-aminoethanethiol disulfide 10% of activity compared to L-Cys Morganella morganii ?
-
 ?
6.3.2.5 ATP + (R)-4'-phosphopantothenate + 2-methylcysteine
-
 Rattus norvegicus N-(phosphopantothenyl)-alpha-methylcysteine + ADP + phosphate
-
 ?
6.3.2.5 ATP + (R)-4'-phosphopantothenate + 2-methylcysteine 10% of the activity compared to L-cysteine Morganella morganii N-(phosphopantothenyl)-alpha-methylcysteine + ADP + phosphate
-
 ?
6.3.2.5 ATP + (R)-4'-phosphopantothenate + beta-mercaptoethylamine
-
 Rattus norvegicus phosphopantetheine + ADP + phosphate
-
 ?
6.3.2.5 ATP + (R)-4'-phosphopantothenate + beta-mercaptoethylamine 25% of activity compared to L-Cys Morganella morganii phosphopantetheine + ADP + phosphate
-
 ?
6.3.2.5 ATP + (R)-4'-phosphopantothenate + cystine 5% of activity compared to L-Cys Morganella morganii (R)-4'-phosphopantothenoyl-L-cystine + ADP + phosphate
-
 ?
6.3.2.5 ATP + (R)-4'-phosphopantothenate + L-Cys
-
 Rattus norvegicus (R)-4'-phosphopantothenoyl-L-cysteine + ADP + phosphate
-
 ?
6.3.2.5 ATP + (R)-4'-phosphopantothenate + L-Cys mammalian enzyme differs from the bacterial enzyme in that it can use any of the other nucleotide triphosphates equally as well as CTP Mammalia (R)-4'-phosphopantothenoyl-L-cysteine + ADP + phosphate
-
 ?
6.3.2.5 CTP + (R)-4'-phosphopantothenate + L-Cys CTP specifically required Mammalia (R)-4'-phosphopantothenoyl-L-cysteine + CDP + phosphate
-
 ?
6.3.2.5 CTP + (R)-4'-phosphopantothenate + L-Cys CTP specifically required Escherichia coli (R)-4'-phosphopantothenoyl-L-cysteine + CDP + phosphate
-
 ?
6.3.2.5 CTP + (R)-4'-phosphopantothenate + L-Cys CTP specifically required Morganella morganii (R)-4'-phosphopantothenoyl-L-cysteine + CDP + phosphate
-
 ?
6.3.2.5 CTP + (R)-4'-phosphopantothenate + L-Cys mammalian enzyme differs from the bacterial enzyme in that it can use any of the other nucleotide triphosphates equally as well as CTP Bacteria (R)-4'-phosphopantothenoyl-L-cysteine + CDP + phosphate
-
 ?