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Literature summary extracted from

  • Bauer, W.; Zenk, M.H.
    Formation of (R)-configurated tetrahydroberberine alkaloids in vivo and in vitro (1991), Tetrahedron Lett., 32, 487-490.
No PubMed abstract available

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.5.1.31 berberine + NADPH Corydalis cava (R)-tetrahydroberberines are formed from protoberberines by a highly stereoselective reduction system canadine + NADP+
-
 r

Organism

EC Number Organism UniProt Comment Textmining
1.5.1.31 Corydalis cava
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.5.1.31 bulb
-
 Corydalis cava
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.5.1.31 7,8-dihydroberberine + NADPH at 64% of the activity with palmatine and NADPH Corydalis cava canadine + NADP+
-
 r
1.5.1.31 berberine + NADH at 59% of the activity with palmatine. At 15% of the activity with berberine and NADPH Corydalis cava canadine + NAD+
-
 r
1.5.1.31 berberine + NADPH at 59% of the activity with palmatine and NADPH Corydalis cava canadine + NADP+
-
 r
1.5.1.31 berberine + NADPH (R)-tetrahydroberberines are formed from protoberberines by a highly stereoselective reduction system Corydalis cava canadine + NADP+
-
 r
1.5.1.31 columbamine + NADPH at 39% of the activity with palmatine and NADPH Corydalis cava ? + NADP+
-
 r
1.5.1.31 coptisine + NADPH at 47% of the activity with palmatine and NADPH Corydalis cava ? + NADP+
-
 r
1.5.1.31 dehydroscoulerine + NADPH at 5% of the activity with palmatine and NADPH Corydalis cava ? + NADP+
-
 r
1.5.1.31 dihydrosinactine + NADPH at 52% of the activity with palmatine and NADPH Corydalis cava ? + NADP+
-
 r
1.5.1.31 jatrorrhizine + NADPH at 25% of the activity with palmatine and NADPH Corydalis cava ? + NADP+
-
 r
1.5.1.31 palmatine + NADPH
-
 Corydalis cava ? + NADP+
-
 r

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.5.1.31 30
-
-
 Corydalis cava

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.5.1.31 7.5
-
-
 Corydalis cava

Cofactor

EC Number Cofactor Comment Organism Structure
1.5.1.31 NADH at 15% of the activity with NADPH Corydalis cava
1.5.1.31 NADP+
-
 Corydalis cava
1.5.1.31 NADPH
-
 Corydalis cava