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Literature summary extracted from

  • Sheng, H.; Ignarro, L.J.
    Biochemical and immunohistochemical characterization of nitric oxide synthase in the rat retina (1996), Pharm. Res., 33, 29-34.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.13.39 Calmidazolium in absence of calmodulin Rattus norvegicus
1.14.13.39 Trifluoperazine in absence of calmodulin Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.14.13.39 cytosol
-
 Rattus norvegicus 5829
-
1.14.13.39 additional information 3 isoforms: 1. neuronal, soluble isoform I is constitutively expressed in brain and other tissues and Ca2+-regulated, 2. soluble isoform II is usually not constitutively expressed, but inducible in macrophages and other cells, 3. isoform III is membrane-bound and expressed in endothelial cells Rattus norvegicus
-
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.14.13.39 Ca2+ cerebellum enzyme is Ca2+-dependent Rattus norvegicus
1.14.13.39 Ca2+ retina enzyme is dependent on Ca2+ Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
1.14.13.39 Rattus norvegicus
-
 Wistar strain
-
1.14.13.39 Rattus norvegicus Wistar
-
 Wistar strain
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.13.39 brain
-
 Rattus norvegicus
-
1.14.13.39 cerebellum
-
 Rattus norvegicus
-
1.14.13.39 additional information 3 isoforms: 1. neuronal, soluble isoform I is constitutively expressed in brain and other tissues and Ca2+-regulated, 2. soluble isoform II is usually not constitutively expressed, but inducible in macrophages and other cells, 3. isoform III is membrane-bound and expressed in endothelial cells Rattus norvegicus
-
1.14.13.39 retina constitutive, soluble form Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.13.39 2 L-arginine + 3 NADPH + 4 O2 + 3 H+
-
 Rattus norvegicus 2 L-citrulline + 2 NO + 3 NADP+ + 4 H2O
-
 ?
1.14.13.39 2 L-arginine + 3 NADPH + 4 O2 + 3 H+
-
 Rattus norvegicus Wistar 2 L-citrulline + 2 NO + 3 NADP+ + 4 H2O
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.14.13.39 37
-
 assay at Rattus norvegicus