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Literature summary extracted from

  • Foerstermann, U.; Closs, E.I.; Pollock, J.S.; Nakane, M.; Schwarz, P.; Gath, I.; Kleinert, H.
    Nitric oxide synthase isoenzymes. Characterization, purification, molecular cloning, and functions (1994), Hypertension, 23, 1121-1131.
    View publication on PubMed

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.14.13.39 0.0029
-
L-arginine isoform III Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.14.13.39 additional information 3 isoforms: 1. neuronal, soluble isoform I is constitutively expressed in brain and other tissues and Ca2+-regulated, 2. soluble isoform II is usually not constitutively expressed, but inducible in macrophages and other cells, 3. isoform III is membrane-bound and expressed in endothelial cells Mus musculus
-
-
1.14.13.39 additional information 3 isoforms: 1. neuronal, soluble isoform I is constitutively expressed in brain and other tissues and Ca2+-regulated, 2. soluble isoform II is usually not constitutively expressed, but inducible in macrophages and other cells, 3. isoform III is membrane-bound and expressed in endothelial cells Homo sapiens
-
-
1.14.13.39 additional information 3 isoforms: 1. neuronal, soluble isoform I is constitutively expressed in brain and other tissues and Ca2+-regulated, 2. soluble isoform II is usually not constitutively expressed, but inducible in macrophages and other cells, 3. isoform III is membrane-bound and expressed in endothelial cells Rattus norvegicus
-
-
1.14.13.39 additional information 3 isoforms: 1. neuronal, soluble isoform I is constitutively expressed in brain and other tissues and Ca2+-regulated, 2. soluble isoform II is usually not constitutively expressed, but inducible in macrophages and other cells, 3. isoform III is membrane-bound and expressed in endothelial cells Sus scrofa
-
-
1.14.13.39 additional information 3 isoforms: 1. neuronal, soluble isoform I is constitutively expressed in brain and other tissues and Ca2+-regulated, 2. soluble isoform II is usually not constitutively expressed, but inducible in macrophages and other cells, 3. isoform III is membrane-bound and expressed in endothelial cells Bos taurus
-
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.14.13.39 160000
-
x * 160000, isoform I, amino acid sequence determination Homo sapiens
1.14.13.39 160000
-
x * 160000, isoform I, amino acid sequence determination Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.13.39 2 L-arginine + 3 NADPH + 4 O2 + 3 H+ Mus musculus physiological functions and pathophysiology of the isoforms 2 L-citrulline + 2 NO + 3 NADP+ + 4 H2O
-
?
1.14.13.39 2 L-arginine + 3 NADPH + 4 O2 + 3 H+ Homo sapiens physiological functions and pathophysiology of the isoforms 2 L-citrulline + 2 NO + 3 NADP+ + 4 H2O
-
?
1.14.13.39 2 L-arginine + 3 NADPH + 4 O2 + 3 H+ Rattus norvegicus physiological functions and pathophysiology of the isoforms 2 L-citrulline + 2 NO + 3 NADP+ + 4 H2O
-
?
1.14.13.39 2 L-arginine + 3 NADPH + 4 O2 + 3 H+ Sus scrofa physiological functions and pathophysiology of the isoforms 2 L-citrulline + 2 NO + 3 NADP+ + 4 H2O
-
?
1.14.13.39 2 L-arginine + 3 NADPH + 4 O2 + 3 H+ Bos taurus physiological functions and pathophysiology of the isoforms 2 L-citrulline + 2 NO + 3 NADP+ + 4 H2O
-
?

Organism

EC Number Organism UniProt Comment Textmining
1.14.13.39 Bos taurus
-
-
-
1.14.13.39 Homo sapiens
-
-
-
1.14.13.39 Mus musculus
-
-
-
1.14.13.39 Rattus norvegicus
-
-
-
1.14.13.39 Sus scrofa
-
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
1.14.13.39 2 L-arginine + 3 NADPH + 3 H+ + 4 O2 = 2 L-citrulline + 2 nitric oxide + 3 NADP+ + 4 H2O isoform I and II are regulated by Ca2+/calmodulin, isoform II is Ca2+-independent, but requires calmodulin, inducible by cytokines Mus musculus
1.14.13.39 2 L-arginine + 3 NADPH + 3 H+ + 4 O2 = 2 L-citrulline + 2 nitric oxide + 3 NADP+ + 4 H2O isoform I and II are regulated by Ca2+/calmodulin, isoform II is Ca2+-independent, but requires calmodulin, inducible by cytokines Homo sapiens
1.14.13.39 2 L-arginine + 3 NADPH + 3 H+ + 4 O2 = 2 L-citrulline + 2 nitric oxide + 3 NADP+ + 4 H2O isoform I and II are regulated by Ca2+/calmodulin, isoform II is Ca2+-independent, but requires calmodulin, inducible by cytokines Rattus norvegicus
1.14.13.39 2 L-arginine + 3 NADPH + 3 H+ + 4 O2 = 2 L-citrulline + 2 nitric oxide + 3 NADP+ + 4 H2O isoform I and II are regulated by Ca2+/calmodulin, isoform II is Ca2+-independent, but requires calmodulin, inducible by cytokines Sus scrofa
1.14.13.39 2 L-arginine + 3 NADPH + 3 H+ + 4 O2 = 2 L-citrulline + 2 nitric oxide + 3 NADP+ + 4 H2O isoform I and II are regulated by Ca2+/calmodulin, isoform II is Ca2+-independent, but requires calmodulin, inducible by cytokines Bos taurus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.13.39 adrenal gland
-
Bos taurus
-
1.14.13.39 adrenal gland isoform I Homo sapiens
-
1.14.13.39 adrenal gland isoform I Rattus norvegicus
-
1.14.13.39 adrenal gland isoform I Sus scrofa
-
1.14.13.39 brain
-
Mus musculus
-
1.14.13.39 brain
-
Bos taurus
-
1.14.13.39 brain isoform I Homo sapiens
-
1.14.13.39 brain isoform I Rattus norvegicus
-
1.14.13.39 brain isoform I Sus scrofa
-
1.14.13.39 chondrocyte
-
Homo sapiens
-
1.14.13.39 DLD-1 cell
-
Homo sapiens
-
1.14.13.39 endothelium isoform III Mus musculus
-
1.14.13.39 endothelium isoform III Homo sapiens
-
1.14.13.39 endothelium isoform III Rattus norvegicus
-
1.14.13.39 endothelium isoform III Sus scrofa
-
1.14.13.39 endothelium isoform III Bos taurus
-
1.14.13.39 endothelium liver, lung, adrenal glandcolon, isoform II Mus musculus
-
1.14.13.39 endothelium liver, lung, adrenal glandcolon, isoform II Homo sapiens
-
1.14.13.39 endothelium liver, lung, adrenal glandcolon, isoform II Rattus norvegicus
-
1.14.13.39 endothelium lung, uterus, stomach Homo sapiens
-
1.14.13.39 endothelium lung, uterus, stomach Rattus norvegicus
-
1.14.13.39 endothelium lung, uterus, stomach Sus scrofa
-
1.14.13.39 hepatocyte isoform II Mus musculus
-
1.14.13.39 hepatocyte isoform II Homo sapiens
-
1.14.13.39 hepatocyte isoform II Rattus norvegicus
-
1.14.13.39 kidney macula densa cells, isoform I Homo sapiens
-
1.14.13.39 kidney macula densa cells, isoform I Rattus norvegicus
-
1.14.13.39 kidney macula densa cells, isoform I Sus scrofa
-
1.14.13.39 liver
-
Mus musculus
-
1.14.13.39 liver
-
Homo sapiens
-
1.14.13.39 liver
-
Rattus norvegicus
-
1.14.13.39 macrophage
-
Bos taurus
-
1.14.13.39 macrophage in liver, lung, kidney, isoform II Mus musculus
-
1.14.13.39 macrophage in liver, lung, kidney, isoform II Homo sapiens
-
1.14.13.39 macrophage in liver, lung, kidney, isoform II Rattus norvegicus
-
1.14.13.39 additional information 3 isoforms: 1. neuronal, soluble isoform I is constitutively expressed in brain and other tissues and Ca2+-regulated, 2. soluble isoform II is usually not constitutively expressed, but inducible in macrophages and other cells, 3. isoform III is membrane-bound and expressed in endothelial cells Mus musculus
-
1.14.13.39 additional information 3 isoforms: 1. neuronal, soluble isoform I is constitutively expressed in brain and other tissues and Ca2+-regulated, 2. soluble isoform II is usually not constitutively expressed, but inducible in macrophages and other cells, 3. isoform III is membrane-bound and expressed in endothelial cells Homo sapiens
-
1.14.13.39 additional information 3 isoforms: 1. neuronal, soluble isoform I is constitutively expressed in brain and other tissues and Ca2+-regulated, 2. soluble isoform II is usually not constitutively expressed, but inducible in macrophages and other cells, 3. isoform III is membrane-bound and expressed in endothelial cells Rattus norvegicus
-
1.14.13.39 additional information 3 isoforms: 1. neuronal, soluble isoform I is constitutively expressed in brain and other tissues and Ca2+-regulated, 2. soluble isoform II is usually not constitutively expressed, but inducible in macrophages and other cells, 3. isoform III is membrane-bound and expressed in endothelial cells Sus scrofa
-
1.14.13.39 additional information 3 isoforms: 1. neuronal, soluble isoform I is constitutively expressed in brain and other tissues and Ca2+-regulated, 2. soluble isoform II is usually not constitutively expressed, but inducible in macrophages and other cells, 3. isoform III is membrane-bound and expressed in endothelial cells Bos taurus
-
1.14.13.39 neuron
-
Mus musculus
-
1.14.13.39 neuron peripheral nitrergic nerves, isoform I Homo sapiens
-
1.14.13.39 neuron peripheral nitrergic nerves, isoform I Rattus norvegicus
-
1.14.13.39 neuron peripheral nitrergic nerves, isoform I Sus scrofa
-
1.14.13.39 pancreas
-
Bos taurus
-
1.14.13.39 pancreas islet cells, isoform I Homo sapiens
-
1.14.13.39 pancreas islet cells, isoform I Rattus norvegicus
-
1.14.13.39 pancreas islet cells, isoform I Sus scrofa
-
1.14.13.39 smooth muscle
-
Rattus norvegicus
-
1.14.13.39 spinal cord isoform I Homo sapiens
-
1.14.13.39 spinal cord isoform I Rattus norvegicus
-
1.14.13.39 spinal cord isoform I Sus scrofa
-
1.14.13.39 spleen red pulp, eosinophils and neutrophils, isoform II Mus musculus
-
1.14.13.39 spleen red pulp, eosinophils and neutrophils, isoform II Homo sapiens
-
1.14.13.39 spleen red pulp, eosinophils and neutrophils, isoform II Rattus norvegicus
-
1.14.13.39 sympathetic ganglion isoform I Homo sapiens
-
1.14.13.39 sympathetic ganglion isoform I Rattus norvegicus
-
1.14.13.39 sympathetic ganglion isoform I Sus scrofa
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.13.39 2 L-arginine + 3 NADPH + 4 O2 + 3 H+
-
Mus musculus 2 L-citrulline + 2 NO + 3 NADP+ + 4 H2O
-
?
1.14.13.39 2 L-arginine + 3 NADPH + 4 O2 + 3 H+
-
Homo sapiens 2 L-citrulline + 2 NO + 3 NADP+ + 4 H2O
-
?
1.14.13.39 2 L-arginine + 3 NADPH + 4 O2 + 3 H+
-
Rattus norvegicus 2 L-citrulline + 2 NO + 3 NADP+ + 4 H2O
-
?
1.14.13.39 2 L-arginine + 3 NADPH + 4 O2 + 3 H+
-
Sus scrofa 2 L-citrulline + 2 NO + 3 NADP+ + 4 H2O
-
?
1.14.13.39 2 L-arginine + 3 NADPH + 4 O2 + 3 H+
-
Bos taurus 2 L-citrulline + 2 NO + 3 NADP+ + 4 H2O
-
?
1.14.13.39 2 L-arginine + 3 NADPH + 4 O2 + 3 H+ physiological functions and pathophysiology of the isoforms Mus musculus 2 L-citrulline + 2 NO + 3 NADP+ + 4 H2O
-
?
1.14.13.39 2 L-arginine + 3 NADPH + 4 O2 + 3 H+ physiological functions and pathophysiology of the isoforms Homo sapiens 2 L-citrulline + 2 NO + 3 NADP+ + 4 H2O
-
?
1.14.13.39 2 L-arginine + 3 NADPH + 4 O2 + 3 H+ physiological functions and pathophysiology of the isoforms Rattus norvegicus 2 L-citrulline + 2 NO + 3 NADP+ + 4 H2O
-
?
1.14.13.39 2 L-arginine + 3 NADPH + 4 O2 + 3 H+ physiological functions and pathophysiology of the isoforms Sus scrofa 2 L-citrulline + 2 NO + 3 NADP+ + 4 H2O
-
?
1.14.13.39 2 L-arginine + 3 NADPH + 4 O2 + 3 H+ physiological functions and pathophysiology of the isoforms Bos taurus 2 L-citrulline + 2 NO + 3 NADP+ + 4 H2O
-
?

Subunits

EC Number Subunits Comment Organism
1.14.13.39 ?
-
Sus scrofa
1.14.13.39 ? x * 160000, isoform I, amino acid sequence determination Homo sapiens
1.14.13.39 ? x * 160000, isoform I, amino acid sequence determination Rattus norvegicus
1.14.13.39 ? 130000-133000, isoforms II and III, amino acid sequence determination Mus musculus
1.14.13.39 ? 130000-133000, isoforms II and III, amino acid sequence determination Homo sapiens
1.14.13.39 ? 130000-133000, isoforms II and III, amino acid sequence determination Rattus norvegicus
1.14.13.39 ? 130000-133000, isoforms II and III, amino acid sequence determination Bos taurus

Synonyms

EC Number Synonyms Comment Organism
1.14.13.39 cb-NOS isoform I, constitutive, from brain Homo sapiens
1.14.13.39 cb-NOS isoform I, constitutive, from brain Rattus norvegicus
1.14.13.39 cb-NOS isoform I, constitutive, from brain Sus scrofa
1.14.13.39 EC-NOS isoform III, in endothelial cells Mus musculus
1.14.13.39 EC-NOS isoform III, in endothelial cells Homo sapiens
1.14.13.39 EC-NOS isoform III, in endothelial cells Bos taurus
1.14.13.39 i-NOS isoform II, inducible Mus musculus
1.14.13.39 i-NOS isoform II, inducible Homo sapiens
1.14.13.39 i-NOS isoform II, inducible Rattus norvegicus
1.14.13.39 n-NOS isoform I, neuronal enzyme Homo sapiens
1.14.13.39 n-NOS isoform I, neuronal enzyme Rattus norvegicus
1.14.13.39 n-NOS isoform I, neuronal enzyme Sus scrofa