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Literature summary extracted from

  • Werner-Felmayer, G.; Werner, E.R.; Fuchs, D.; Hausen, A.; Mayer, B.; Reibnegger, G.; Weiss, G.; Wachter, H.
    Calcium/calmodulin-dependent nitric oxide synthase activity in the human cervix carcinoma cell line ME-180 (1993), Biochem. J., 289, 357-361.
No PubMed abstract available

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.14.13.39 additional information neopterin derivatives are completely inactive and do not bind to the enzyme Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.13.39 Ngamma-monomethyl-L-arginine
-
 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.14.13.39 cytosol
-
 Homo sapiens 5829
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.14.13.39 Ca2+ absolutely dependent on Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.13.39 additional information Homo sapiens NO represents the endogenous activator of soluble guanylyl cyclase ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.13.39 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.13.39 cervical carcinoma cell cell line ME-180, constitutive expression Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.13.39 2 L-arginine + 3 NADPH + 4 O2 + 3 H+
-
 Homo sapiens 2 L-citrulline + 2 NO + 3 NADP+ + 4 H2O the product is a guanylyl-cyclase-relaxing factor, that is identical with nitric oxide or a NO-releasing compound ?
1.14.13.39 additional information NO represents the endogenous activator of soluble guanylyl cyclase Homo sapiens ?
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.14.13.39 37
-
 assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.14.13.39 8
-
 assay at Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.13.39 5,6,7,8-tetrahydro-L-biopterin required Homo sapiens
1.14.13.39 Calmodulin
-
 Homo sapiens
1.14.13.39 FAD required Homo sapiens
1.14.13.39 FMN required Homo sapiens
1.14.13.39 NADPH dependent on Homo sapiens