Literature summary extracted from

Stuehr, D.J.; Fasehun, O.A.; Kwon, N.S.; Gross, S.S.; Gonzalez, J.A.; Levi, R.; Nathan, C.F.
Inhibition of macrophage and endothelial cell nitric oxide synthase by diphenyleneiodonium and its analogs (1991), FASEB J., 5, 98-103.

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
1.14.13.39	Di-2-thienyliodonium	competitive, irreversible, complete, time and temperature dependent inhibition	Mus musculus
1.14.13.39	diphenylene iodonium	competitive, irreversible, complete, time and temperature dependent inhibition	Mus musculus
1.14.13.39	Iodoniumdiphenyl	competitive, irreversible, complete, time and temperature dependent inhibition	Mus musculus

Organism

EC Number	Organism	UniProt	Comment	Textmining
1.14.13.39	Mus musculus	-	-	-

Purification (Commentary)

EC Number	Purification (Comment)	Organism
1.14.13.39	partial	Mus musculus

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
1.14.13.39	macrophage	-	Mus musculus	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
1.14.13.39	2 L-arginine + 3 NADPH + 4 O2 + 3 H+	-	Mus musculus	2 L-citrulline + 2 NO + 3 NADP+ + 4 H2O	-	?

Temperature Optimum [°C]

EC Number	Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
1.14.13.39	37	-	assay at	Mus musculus

Cofactor

EC Number	Cofactor	Comment	Organism	Structure
1.14.13.39	FAD	-	Mus musculus
1.14.13.39	FMN	-	Mus musculus
1.14.13.39	NADPH	-	Mus musculus

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Release 2023.1 (January 2023)