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Literature summary extracted from
- Nitric oxide synthase from cerebellum catalyzes the formation of equimolar quantities of nitric oxide and citrulline from L-arginine (1992), Biochem. Biophys. Res. Commun., 185, 960-966.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.14.13.39 | Calmidazolium | calmodulin antagonist | Rattus norvegicus |  |
| 1.14.13.39 | Ngamma-amino-L-arginine | - |
Rattus norvegicus | |
| 1.14.13.39 | Ngamma-monomethyl-L-arginine | - |
Rattus norvegicus | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 1.14.13.39 | 0.014 | 0.018 | L-arginine | - |
Rattus norvegicus | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.14.13.39 | Rattus norvegicus | - |
2 isoforms | - |
| 1.14.13.39 | Rattus norvegicus | - |
Sprague-Dawley | - |
| 1.14.13.39 | Rattus norvegicus Sprague-Dawley | - |
Sprague-Dawley | - |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.14.13.39 | brain | - |
Rattus norvegicus | - |
| 1.14.13.39 | cerebellum | - |
Rattus norvegicus | - |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 1.14.13.39 | 0.00074 | - |
crude extract | Rattus norvegicus |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.14.13.39 | 2 L-arginine + 3 NADPH + 4 O2 + 3 H+ | - |
Rattus norvegicus | 2 L-citrulline + 2 NO + 3 NADP+ + 4 H2O | - |
? | |
| 1.14.13.39 | 2 L-arginine + 3 NADPH + 4 O2 + 3 H+ | - |
Rattus norvegicus Sprague-Dawley | 2 L-citrulline + 2 NO + 3 NADP+ + 4 H2O | - |
? | |
Temperature Optimum [°C]
| EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 1.14.13.39 | 37 | - |
assay at | Rattus norvegicus |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 1.14.13.39 | 7.4 | - |
assay at | Rattus norvegicus |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.14.13.39 | NADPH | dependent on | Rattus norvegicus | |
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Release 2023.1 (January 2023)
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