Literature summary extracted from

Bareis, P.; Kallay, E.; Bischof, M.G.; Bises, G.; Hofer, H.; Potzi, C.; Manhardt, T.; Bland, R.; Cross, H.S.
Clonal differences in expression of 25-hydroxyvitamin D(3)-1alpha-hydroxylase, of 25-hydroxyvitamin D(3)-24-hydroxylase, and of the vitamin D receptor in human colon carcinoma cells: effects of epidermal growth factor and 1alpha,25-dihydroxyvitamin D(3) (2002), Exp. Cell Res., 276, 320-327.

Activating Compound

EC Number	Activating Compound	Comment	Organism	Structure
1.14.15.18	1,25-Dihydroxycholecalciferol	increases mRNA expression in highly differentiated cells like Caco-2/15	Homo sapiens
1.14.15.18	Epidermal growth factor	i.e. EGF	Homo sapiens
1.14.15.18	Epidermal growth factor	increases mRNA expression in highly differentiated cells like Caco-2/15	Homo sapiens

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
1.14.15.18	1,25-Dihydroxycholecalciferol	calcitriol; decreases mRNA expression in less differentiated cells like Caco-2/AQ and COGA-1A and -1E	Homo sapiens
1.14.15.18	Epidermal growth factor	decreases mRNA expression in less differentiated cells like Caco-2/AQ and COGA-1A and -1E; i.e. EGF	Homo sapiens

Organism

EC Number	Organism	UniProt	Comment	Textmining
1.14.15.18	Homo sapiens	-	-	-

Reaction

EC Number	Reaction	Comment	Organism	Reaction ID
1.14.15.18	calcidiol + 2 reduced adrenodoxin + 2 H+ + O2 = calcitriol + 2 oxidized adrenodoxin + H2O	cytochrome P-450 enzyme	Homo sapiens	a

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
1.14.15.18	Caco-2 cell	-	Homo sapiens	-
1.14.15.18	colonic carcinoma cell line	cell line COGA	Homo sapiens	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
1.14.15.18	calcidiol + NADPH + O2	highly specific for calcidiol, calcidiol is identical with 25-hydroxycholecalciferol	Homo sapiens	calcitriol + NADP+ + H2O	calcitriol is identical with 1,25-dihydroxycholecalciferol	?

Synonyms

EC Number	Synonyms	Comment	Organism
1.14.15.18	CYB27B1	-	Homo sapiens

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Release 2023.1 (January 2023)