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Literature summary extracted from

  • Hagenfeldt, Y.; Berlin, T.
    The human renal 25-hydroxyvitamin D3-1a-hydroxylase: properties studied by isotope-dilution mass spectrometry (1992), Eur. J. Clin. Invest., 22, 223-228.
    View publication on PubMed

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.14.15.18 0.014
-
 25-hydroxycholecalciferol
-
 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.14.15.18 mitochondrion
-
 Homo sapiens 5739
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.15.18 25-hydroxycholecalciferol + NADPH + O2 Homo sapiens enzyme activity is correlated with phosphate content in serum calcitriol + NADP+ + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.15.18 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.15.18 kidney renal cortex Homo sapiens
-
1.14.15.18 kidney tumour tissue Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.14.15.18 additional information
-
 higher activity in male kidney compared to female kidney Homo sapiens
1.14.15.18 0.0000001
-
 female human kidney Homo sapiens
1.14.15.18 0.0000002
-
 male human kidney Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.15.18 25-hydroxycholecalciferol + NADPH + O2 enzyme activity is correlated with phosphate content in serum Homo sapiens calcitriol + NADP+ + H2O
-
 ?
1.14.15.18 calcidiol + NADPH + O2 highly specific for calcidiol, calcidiol is identical with 25-hydroxycholecalciferol Homo sapiens calcitriol + NADP+ + H2O calcitriol is identical with 1,25-dihydroxycholecalciferol ?